A novel chimeric recombinant FliC-Pgp3 vaccine promotes immunoprotection against Chlamydia muridarum infection in mice

L Zhao, X Wang, Z Li - International Journal of Biological Macromolecules, 2024 - Elsevier
The Pgp3 subunit vaccine elicits immune protection against Chlamydia trachomatis
infection, but additional adjuvants are still required to enhance its immunoprotective efficacy …

Efficacy of Pgp3 vaccination for Chlamydia urogenital tract infection depends on its native conformation

B Peng, S Zhong, Y Hua, Q Luo, W Dong… - Frontiers in …, 2022 - frontiersin.org
Urogenital tract infections with Chlamydia trachomatis have frequently been detected among
patients diagnosed with sexually transmitted infections, and such infections lead to …

Chitosan particle stabilized Pickering emulsion/interleukin-12 adjuvant system for Pgp3 subunit vaccine elicits immune protection against genital chlamydial infection …

M Shu, L Zhao, K Shi, W Lei, Y Yang, Z Li - Frontiers in Immunology, 2022 - frontiersin.org
Considering the shortcomings in current chlamydia infection control strategies, a major
challenge in curtailing infection is the implementation of an effective vaccine. The immune …

Vaccination with MIP or Pgp3 induces cross-serovar protection against chlamydial genital tract infection in mice

X Luan, B Peng, Z Li, L Tang, C Chen, L Chen, H Wu… - Immunobiology, 2019 - Elsevier
Previously we reported that recombinant Chlamydia muridarum macrophage infectivity
potentiator (MIP) provided partial protection against C. muridarum genital tract infection in …

Protection promoted by pGP3 or pGP4 against Chlamydia muridarum is mediated by CD4+ cells in C57BL/6N mice

T Mosolygó, ÁM Szabó, EP Balogh, I Faludi, DP Virók… - Vaccine, 2014 - Elsevier
Urogenital tract infection with Chlamydia trachomatis is a leading cause of sexually
transmitted infections. There is currently no commercially available vaccine against C …

Evaluation of a tandem Chlamydia psittaci Pgp3 multiepitope peptide vaccine against a pulmonary chlamydial challenge in mice

C Wang, Y Li, S Wang, X Yan, J Xiao, Y Chen… - Microbial …, 2020 - Elsevier
Chlamydia psittaci is the pathogen of psittacosis, and it has emerged as a significant public
health threat. Because most infections are easily overlooked, a vaccine is recognized as the …

Cellular Basis for the Enhanced Efficacy of the Fms-Like Tyrosine Kinase 3 Ligand (FL) Adjuvanted VCG-Based Chlamydia abortus Vaccine

S Richardson, F Medhavi, T Tanner, S Lundy… - Frontiers in …, 2021 - frontiersin.org
Efficacious vaccines are needed to control genital chlamydial diseases in humans and the
veterinary industry. We previously reported a C. abortus (Cab) vaccine comprising …

DNA immunization with pgp3 gene of Chlamydia trachomatis inhibits the spread of chlamydial infection from the lower to the upper genital tract in C3H/HeN mice

M Donati, V Sambri, M Comanducci, K Di Leo, E Storni… - Vaccine, 2003 - Elsevier
Chlamydia trachomatis pgp3 DNA immunized (no. 300) and non-immunized (no. 300)
C3H/HeN mice were infected by vaginal inoculation with infectious C. trachomatis serotype …

Heterologous prime-boost vaccination based on Polymorphic protein D protects against intravaginal Chlamydia trachomatis infection in mice

RC Russi, D Del Balzo, A Luján, IG Reidel, MI García… - Scientific Reports, 2022 - nature.com
The control of the worldwide spread of sexually transmitted Chlamydia trachomatis (Ct)
infection urgently demands the development of a preventive vaccine. In this work, we …

A multi-epitope vaccine based on Chlamydia trachomatis major outer membrane protein induces specific immunity in mice

J Tu, B Hou, B Wang, X Lin, W Gong… - Acta Biochim …, 2014 - academic.oup.com
We evaluated the immunogenicity and efficacy of a candidate vaccine comprising the major
outer membrane protein (MOMP) multi-epitope of Chlamydia trachomatis. A short gene of …