Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarcinoma of the uterus

RG Moore, AK Brown, MC Miller, D Badgwell, Z Lu… - Gynecologic …, 2008 - Elsevier
OBJECTIVE: Tumor markers with increased sensitivity and specificity for endometrial cancer
are needed to help monitor response to therapy and to detect recurrent disease. Currently …

HE4 is an independent prognostic marker in endometrial cancer patients

I Mutz-Dehbalaie, D Egle, S Fessler, M Hubalek… - Gynecologic …, 2012 - Elsevier
OBJECTIVE: To evaluate the prognostic value of pretherapeutic serum HE4 in endometrial
cancer in comparison to CA125. METHODS: HE4 and CA125 serum levels were analyzed …

HE4 as a Biomarker for Endometrial Cancer

R Behrouzi, CE Barr, EJ Crosbie - Cancers, 2021 - mdpi.com
Simple Summary There are currently no blood biomarkers approved for routine clinical use
in endometrial cancer. Serum human epididymis protein 4 (HE4) is significantly higher in …

Serum HE4 as a prognostic marker in endometrial cancer—a population based study

DJ Brennan, A Hackethal, AM Metcalf, J Coward… - Gynecologic …, 2014 - Elsevier
Objective HE4 has emerged as a promising biomarker in gynaecological oncology. The
purpose of this study was to evaluate serum HE4 as a biomarker for high-risk phenotypes in …

The role of novel biomarker HE4 in endometrial cancer: a case control prospective study

R Angioli, F Plotti, S Capriglione, R Montera, P Damiani… - Tumor Biology, 2013 - Springer
The aim of the study was to explore the clinical value of serum human epididymis secretory
protein E4 (HE4) and CA125 in endometrial carcinoma. From January 2010 to April 2012 …

Correlation of serum HE4 with tumor size and myometrial invasion in endometrial cancer

E Kalogera, N Scholler, C Powless, A Weaver… - Gynecologic …, 2012 - Elsevier
OBJECTIVE: To evaluate the utility of serum (HE4) as a marker for high risk disease in
patients with endometrial cancer (EC). METHODS: Preoperative serum HE4 levels were …

Diagnostic and prognostic impact of serum HE4 detection in endometrial carcinoma patients

E Bignotti, M Ragnoli, L Zanotti, S Calza… - British journal of …, 2011 - nature.com
Background: To date, no good marker for screening or disease monitoring of endometrial
cancer (EC) is available. The aims of this study were to investigate HE4 gene, protein …

Human epididymis protein 4 as a serum marker for diagnosis of endometrial carcinoma and prediction of clinical outcome

L Zanotti, E Bignotti, S Calza, E Bandiera… - Clinical Chemistry and …, 2012 - degruyter.com
Background: The purpose of this study was to assess the diagnostic and prognostic impact
of preoperative serum determination of human epididymis protein 4 (sHE4), and to …

Clinical significance of serum HE4, CA125, CA724, and CA19-9 in patients with endometrial cancer

J Bian, X Sun, B Li, L Ming - Technology in cancer research …, 2017 - journals.sagepub.com
Purpose: Serum markers with increased sensitivity and specificity for endometrial cancer are
required. To date, no good marker has met this standard. The aims of our study were to …

Utility of tumor marker HE4 to predict depth of myometrial invasion in endometrioid adenocarcinoma of the uterus

RG Moore, CM Miller, AK Brown, K Robison… - International Journal of …, 2011 - ijgc.bmj.com
Objective: The purpose of this pilot study was to determine whether the biomarker human
epididymis protein 4 (HE4) correlates with depth of myometrial invasion, histologic grade …