Abstract The 5-alpha-reductase enzyme, present in pilosebaceous units, plays a crucial role
in the appearance of cutaneous hyperandrogenism manifestations (hirsutism, acne, and …

Androgenetic alopecia is a multifactorial condition characterized by noticeable hair loss,
affecting both men and women and representing a debilitating and chronic disorder that …

Background/Aims: Androgenetic alopecia is an extremely common dermatological disorder
affecting both men and women. Oral finasteride (FNS), a synthetic 4-aza-3-oxosteroid …

Plant-derived 5 α-reductase inhibitors, such as β-sitosterol and phytosterol glycosides, have
been used to treat androgenic alopecia, but their oral absolute bioavailability is poor. This …

Alopecia areata is managed with oral corticosteroids, which has known side effects for
patients. Given that a topical application of formulations containing a corticoid and a …

Abstract Finasteride (FIN), a 5-α reductase enzyme inhibitor is mainly used orally for the
treatment of androgenic alopecia and benign prostate hyperplasia. The present study was …

The fundamental purpose of this study was to develop a stable lyophilised finasteride
nanosystem (FNS-NS) for topical delivery. The FNS-NS was fabricated using an …

Alopecia is a treatable disorder that usually occurs due to high levels of 5‐alpha
dihydrotestosterone in hair follicles. To enhance the storage capacity of hair follicles and …

This study proposes developing a topical formulation based on poly-ε-caprolactone (PCL) or
methacrylic acid/methyl methacrylate copolymer (EL100) nanoparticles to enable a safer …

In the present study, iron oxide nanoparticles, in the form of maghemite core coated with
lauric acid (ION), were synthesized and loaded with finasteride (FIN) or dutasteride (DUT) as …