Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products
sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways …

Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products
sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways …

In recent years, the antidepressant activity of Hypericum perforatum, commonly known as St.
John's wort, has attracted much attention from both scientists1-4 and the wider public. 5 …

With their fascinating biological profiles and stunningly complex molecular architectures, the
polycyclic polyprenylated acylphloroglucinols (PPAPs) have long provided a fertile playing …

A 10-step total synthesis of the polycyclic polyprenylated acylphloroglucinol (PPAP) natural
product hyperforin from 2-methylcyclopent-2-en-1-one is reported. This route was enabled …

Hyperforin is a polyprenylated acylphloroglucinol derivative from Hypericum perforatum (St.
John's wort). It exhibits antidepressant activity by a novel mechanism of action, antibiotic …

Polyprenylated polycyclic acylphloroglucines (PPAPs) are a family of natural products that
possess a wide range of different important biological activities because of the relative …

A concise approach to the bicyclo [3.3. 1] nonane framework of the polyprenylated
phloroglucinol natural products utilizing a tandem alkylative dearomatization− annulation …

Biomimetic syntheses of three polycylic polyprenylated acylphloroglucinol natural products
isolated from Hypericum papuanum, ialibinone A, ialibinone B, and hyperguinone B, have …

The aim of this review is to present a detailed account of all published synthetic approaches
toward the [3.3. 1] bridged bicyclic class of phloroglucinol natural products most famously …