Error-free chromosome segregation relies on stable connections between kinetochores and
spindle microtubules. The spindle assembly checkpoint (SAC) monitors such connections …

Kinetochores generate a signal that inhibits anaphase progression until every kinetochore
makes proper attachments to spindle microtubules. This spindle assembly checkpoint (SAC) …

Cell division culminates in the segregation of duplicated chromosomes in opposite
directions prior to cellular fission. This process is guarded by the spindle assembly …

With the goal of creating two genetically identical daughter cells, cell division culminates in
the equal segregation of sister chromatids. This phase of cell division is monitored by a cell …

The transmission of a complete set of chromosomes to daughter cells during cell division is
vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) …

Faithful chromosome segregation during mitosis is crucial for maintaining genome stability.
The spindle assembly checkpoint (SAC) is a surveillance mechanism that ensures accurate …

The spindle assembly checkpoint (SAC) is a surveillance mechanism that promotes
accurate chromosome segregation in mitosis. The checkpoint senses the attachment state of …

Recent high-resolution studies of kinetochore structure have transformed the way
researchers think about this crucial macro-molecular complex, which is essential for …

The spindle assembly checkpoint (SAC) is a unique signalling mechanism that responds to
the state of attachment of the kinetochore to spindle microtubules. SAC signalling is …

In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore,
a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches …