Recent advances in liver engineering with decellularized scaffold

Q Dai, W Jiang, F Huang, F Song, J Zhang… - … in Bioengineering and …, 2022 - frontiersin.org
Liver transplantation is currently the only effective treatment for patients with end-stage liver
disease; however, donor liver scarcity is a notable concern. As a result, extensive endeavors …

Advances in hepatic tissue bioengineering with decellularized liver bioscaffold

EA Rossi, LF Quintanilha, CKV Nonaka… - Stem cells …, 2019 - Wiley Online Library
The burden of liver diseases continues to grow worldwide, and liver transplantation is the
only option for patients with end‐stage liver disease. This procedure is limited by critical …

Recent advances in decellularization and recellularization for tissue-engineered liver grafts

Y Wang, CT Nicolas, HS Chen, JJ Ross… - Cells Tissues …, 2017 - karger.com
Liver transplantation from deceased or living human donors remains the only proven option
for patients with end-stage liver disease. However, the shortage of donor organs is a …

Decellularization and cell seeding of whole liver biologic scaffolds composed of extracellular matrix

DM Faulk, JD Wildemann, SF Badylak - Journal of clinical and experimental …, 2015 - Elsevier
The definitive treatment for patients with end-stage liver disease is orthotropic
transplantation. However, this option is limited by the disparity between the number of …

A hepatic scaffold from decellularized liver tissue: food for thought

S Croce, A Peloso, T Zoro, MA Avanzini, L Cobianchi - Biomolecules, 2019 - mdpi.com
Allogeneic liver transplantation is still deemed the gold standard solution for end-stage
organ failure; however, donor organ shortages have led to extended waiting lists for organ …

Recent advances in optimization of liver decellularization procedures used for liver regeneration

M Khajavi, M Hashemi, F Kalalinia - Life Sciences, 2021 - Elsevier
Severe liver diseases have been considered the most common causes of adult deaths
worldwide. Until now, liver transplantation is known as the only effective treatment for end …

Engineered liver for transplantation

BE Uygun, ML Yarmush - Current opinion in biotechnology, 2013 - Elsevier
Highlights•Engineering liver tissue addresses the shortage of donor organs for
transplantation.•Survival of liver constructs largely depends on efficiency of nutrient delivery …

Decellularization techniques for tissue engineering: towards replicating native extracellular matrix architecture in liver regeneration

I Allu, AK Sahi, M Koppadi, S Gundu… - Journal of Functional …, 2023 - mdpi.com
The process of tissue regeneration requires the utilization of a scaffold, which serves as a
structural framework facilitating cellular adhesion, proliferation, and migration within a …

Stem cells with decellularized liver scaffolds in liver regeneration and their potential clinical applications

Q Zhou, L Li, J Li - Liver international, 2015 - Wiley Online Library
End‐stage hepatic failure is a potentially life‐threatening condition for which orthotopic liver
transplantation (OLT) is the only effective treatment. However, a shortage of available donor …

Decellularized human liver is too heterogeneous for designing a generic extracellular matrix mimic hepatic scaffold

G Mattei, C Magliaro, A Pirone, A Ahluwalia - Artificial organs, 2017 - Wiley Online Library
Decellularized human livers are considered the perfect extracellular matrix (ECM) surrogate
because both three‐dimensional architecture and biological features of the hepatic …