We have produced a surrogate erythrocyte ('hemosomes') by encapsulating human
hemoglobin in polymerized vesicles composed of diacetylenic phospholipids plus or minus …

By incorporating the lipid-heme in the polymerized liposome, conc. and mechanically stable
heme solution ([heme]= 10 mM) was prepared; this solution (100 ml) could bind molecular …

Hemoglobin (Hb) was encapsulated in phosphatidylcholine vesicles by removal of the
detergent n-octyl β-d-glucoside (OG) or n-octyltetraoxyethylene (C 8 E 4) out of mixed …

Liposome-encapsulated hemoglobin (LEH) is being developed at the Naval Research
Laboratory as a universally transfusable oxygen-carrying blood replacement. A chemical …

Copolymerized liposome of l, 2-bis (octadeca-2', 4'-dienoyl)-sra-glycero-3-phosphocholine
and sodium 15-(l'-imidazolyl) pentadeca-irons-2, trons-4-dienoate is an effective carrier of …

Lipid bilayer membranes have been used to encapsulate hemoglobin and organic
phosphates, resulting in a synthetic red cell with oxygen-binding properties very similar to …

(57 ABSTRACT A method for making sterile liposome-encapsulated hemoglobin having an
oxygen carrying capacity of 20 vol/%, a half life of 15-20 hours as measured in mice, with the …

A study was made of the in vitro stability of hemoglobin-containing liposomes ('hemosomes')
prepared from phosphatidylcholines, equimolar cholesterol and red cell lysate by the hand …

Publisher Summary This chapter discusses a method for encapsulating a high concentration
of hemoglobin in liposomes for use as a high-capacity artificial oxygen-carrying system. This …

Synthetic erythrocytes have been formed by encapsulating concentrated hemoglobin
solutions in microcapsules consisting of phospholipid-cholesterol mixtures. The …