Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus
During hippocampal neuron differentiation, the expression of critical inducers of non-
neuronal cell lineages must be efficiently silenced. Runx2 transcription factor is the master …
neuronal cell lineages must be efficiently silenced. Runx2 transcription factor is the master …
Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus
During hippocampal neuron differentiation, the expression of critical inducers of non-
neuronal cell lineages must be efficiently silenced. Runx2 transcription factor is the master …
neuronal cell lineages must be efficiently silenced. Runx2 transcription factor is the master …
Epigenetic silencing of the osteoblast‐lineage gene program during hippocampal maturation
R Aguilar, FJ Bustos, G Nardocci… - Journal of cellular …, 2021 - Wiley Online Library
Accumulating evidence indicates that epigenetic control of gene expression plays a
significant role during cell lineage commitment and subsequent cell fate maintenance. Here …
significant role during cell lineage commitment and subsequent cell fate maintenance. Here …
[HTML][HTML] Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages
The transcriptional regulator Runx2 (runt-related transcription factor 2) has essential but
distinct roles in osteoblasts and chondrocytes in skeletal development. However, Runx2 …
distinct roles in osteoblasts and chondrocytes in skeletal development. However, Runx2 …
Epigenetic landscape during osteoblastogenesis defines a differentiation-dependent Runx2 promoter region
Runx2 is a developmentally regulated gene in vertebrates and is essential for bone
formation and skeletal homeostasis. The induction of runx2-P1 isoform transcripts is a …
formation and skeletal homeostasis. The induction of runx2-P1 isoform transcripts is a …
[PDF][PDF] Multiple Conserved Enhancers of the Osteoblast Master Transcription Factor, Runx2, Integrate Diverse Signaling Pathways to Direct Expression to Developing …
CW Weber - 2013 - core.ac.uk
The vertebrate skeleton forms via two distinct modes of ossification, membranous and
endochondral. Osteoblasts are also heterogeneous in embryonic origin; bone formed by …
endochondral. Osteoblasts are also heterogeneous in embryonic origin; bone formed by …
Mitotic inheritance of mRNA facilitates translational activation of the osteogenic‐Lineage commitment factor runx2 in progeny of osteoblastic cells
Epigenetic mechanisms mediate the acquisition of specialized cellular phenotypes during
tissue development, maintenance and repair. When phenotype‐committed cells transit …
tissue development, maintenance and repair. When phenotype‐committed cells transit …
MAP Kinase‐dependent RUNX2 phosphorylation is necessary for epigenetic modification of chromatin during osteoblast differentiation
Y Li, C Ge, RT Franceschi - Journal of cellular physiology, 2017 - Wiley Online Library
RUNX2, an essential transcription factor for osteoblast differentiation and bone formation is
activated by ERK/MAP kinase‐dependent phosphorylation. However, relationship between …
activated by ERK/MAP kinase‐dependent phosphorylation. However, relationship between …
Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells
N Varela Figueroa, KA Aránguiz Quezada, C Lizama… - 2016 - repositorio.uchile.cl
Epigenetic mechanisms mediate the acquisition of specialized cellular phenotypes during
tissue development, maintenance and repair. When phenotype-committed cells transit …
tissue development, maintenance and repair. When phenotype-committed cells transit …
A Helix‐Loop‐Helix Motif within a Genomic DNaseI Footprint of the Runx2 Gene Promoter is Essential for Basal Bone Tissue‐Specific Transcription
Y Zhang, H Hovhannisyan, MQ Hassan… - The FASEB …, 2010 - Wiley Online Library
Transcriptional mechanisms controlling Runx2 levels are critical for its osteogenic function
during osteoblast differentiation. Here we examine the chromatin organization of the …
during osteoblast differentiation. Here we examine the chromatin organization of the …