Abstract Overexpression of Cyclooxygenase‐2 (COX‐2) is observed in most tumor types.
Increased COX‐2 activity and synthesis of prostaglandins stimulates proliferation …

Cyclooxygenase-2 (COX-2), an endoplasmic reticulum-resident protein, has been known to
promote tumorigenesis, but the exact mechanisms involved have not been identified. We …

Abstract Cyclooxygenase-2 (COX-2) has been implicated in a variety of human
malignancies and, accordingly, COX-2 selective inhibitors are being investigated as …

Although p53-inactivating mutations have been described in the majority of human cancers,
their role in prostate cancer is controversial as mutations are uncommon, particularly in early …

Abstract Overexpression of cyclooxygenase-2 (Cox-2) is thought to exert antiapoptotic
effects in cancer. Here we show that the tumor suppressor p53 upregulated Cox-2 in …

We have previously shown that p53 induces cyclooxygenase-2 (COX-2) expression and
COX-2 inhibits p53-or genotoxic stress-induced apoptosis. However, the COX-2 effects have …

The identification of transcriptional targets of the tumor suppressor p53 is crucial in
understanding mechanisms by which it affects cellular outcomes. Through expression array …

Non-small cell lung Cancer (NSCLC) is extremely resistant to chemotherapeutic agents,
such as cisplatin. High expression of the inflammatory enzyme Cyclooxygenase-2 (COX-2) …

Oncogenes enhance the expression of cyclooxygenase (Cox)-2, but interactions between
tumor suppressor genes and Cox-2 have not been studied. In the present work, we have …

The immediate-early gene, cyclooxygenase-2 (COX-2), is induced in a variety of
inflammatory and neoplastic processes and is believed to play an important role in …