Biomarkers to diagnose ventricular dysfunction in childhood cancer survivors: a systematic review

JM Leerink, SJ Verkleij, EAM Feijen… - Heart, 2019 - heart.bmj.com
Objective To systematically review the literature and assess the diagnostic value of
biomarkers in detection of late-onset left ventricular (LV) dysfunction in childhood cancer …

Cardiac biomarkers for the detection of cardiotoxicity in childhood cancer—a meta‐analysis

L Michel, RI Mincu, SM Mrotzek, S Korste… - ESC Heart …, 2020 - Wiley Online Library
Aims Childhood cancer therapy is associated with a significant risk of therapy‐related
cardiotoxicity. This meta‐analysis aims to evaluate cardiac biomarkers for the detection of …

A biomarker-based diagnostic model for cardiac dysfunction in childhood cancer survivors

JM Leerink, EAM Feijen, EC de Baat, R Merkx… - Cardio Oncology, 2024 - jacc.org
Background Childhood cancer survivors at risk for heart failure undergo lifelong
echocardiographic surveillance. Previous studies reported the limited diagnostic accuracy of …

Screening for cardiac dysfunction in anthracycline-exposed childhood cancer survivors

SH Armenian, SK Gelehrter, T Vase… - Clinical Cancer …, 2014 - AACR
Purpose: To examine the utility and reliability of obtaining early echocardiographic
measurements of left ventricular (LV) remodeling as well as blood biomarkers of cardiac …

Cardiac Function After Cardiotoxic Treatments for Childhood Cancer—Left Ventricular Longitudinal Strain in Screening

J Niemelä, K Ylänen, A Suominen… - Frontiers in …, 2021 - frontiersin.org
Background: The majority of childhood cancer survivors (CCSs) have been exposed to
cardiotoxic treatments and often present with modifiable cardiovascular risk factors. Our aim …

Cardiac biomarkers indicate a need for sensitive cardiac imaging among long‐term childhood cancer survivors exposed to anthracyclines

K Ylänen, T Poutanen, T Savukoski, A Eerola… - Acta …, 2015 - Wiley Online Library
Aim The role that plasma N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and cardiac
troponins T (cTnT) and I (cTnI) play in supplementing imaging to screen for cardiac late …

Asymptomatic systolic dysfunction on contemporary echocardiography in anthracycline-treated long-term childhood cancer survivors: a systematic review

R Merkx, JM Leerink, EC de Baat, EAM Feijen… - Journal of Cancer …, 2022 - Springer
Purpose Echocardiographic surveillance for asymptomatic left ventricular systolic
dysfunction (ALVSD) is advised in childhood cancer survivors (CCS), because of their risk of …

Improved cardiomyopathy risk prediction using global longitudinal strain and N-terminal-pro-B-type natriuretic peptide in survivors of childhood cancer exposed to …

MJ Ehrhardt, Q Liu, DA Mulrooney, IB Rhea… - Journal of Clinical …, 2024 - ascopubs.org
PURPOSE To leverage baseline global longitudinal strain (GLS) and N-terminal-pro-B-type
natriuretic peptide (NT-proBNP) to identify childhood cancer survivors with a normal left …

Cardiac function in 5-year survivors of childhood cancer: a long-term follow-up study

HJ van der Pal, EC van Dalen… - Archives of internal …, 2010 - jamanetwork.com
Background Childhood cancer survivors (CCSs) have an increased risk of morbidity and
mortality. We evaluated the prevalence and determinants of left ventricular (LV) dysfunction …

Subclinical cardiac dysfunction in childhood cancer survivors on 10-years follow-up correlates with cumulative anthracycline dose and is best detected by …

CM Wolf, B Reiner, A Kühn, A Hager, J Müller… - Frontiers in …, 2020 - frontiersin.org
Background: Survivors of childhood cancer are at risk for anthracycline-and/or radiotherapy-
induced cardiotoxicity. Aims: The aim of this study was to assess clinical, laboratory, and …