Non-invasive assays of cochlear synaptopathy–candidates and considerations
Studies in multiple species, including in post-mortem human tissue, have shown that normal
aging and/or acoustic overexposure can lead to a significant loss of afferent synapses …
aging and/or acoustic overexposure can lead to a significant loss of afferent synapses …
[HTML][HTML] Translational issues in cochlear synaptopathy
Understanding the biology of the previously underappreciated sensitivity of cochlear
synapses to noise insult, and its clinical consequences, is becoming a mission for a growing …
synapses to noise insult, and its clinical consequences, is becoming a mission for a growing …
Enhancing the sensitivity of the envelope-following response for cochlear synaptopathy screening in humans: The role of stimulus envelope
V Vasilkov, M Garrett, M Mauermann, S Verhulst - Hearing Research, 2021 - Elsevier
Auditory de-afferentation, a permanent reduction in the number of inner-hair-cells and
auditory-nerve synapses due to cochlear damage or synaptopathy, can reliably be …
auditory-nerve synapses due to cochlear damage or synaptopathy, can reliably be …
Toward a diagnostic test for hidden hearing loss
Cochlear synaptopathy (or hidden hearing loss), due to noise exposure or aging, has been
demonstrated in animal models using histological techniques. However, diagnosis of the …
demonstrated in animal models using histological techniques. However, diagnosis of the …
Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline
Y Sergeyenko, K Lall, MC Liberman… - Journal of …, 2013 - Soc Neuroscience
Aging listeners experience greater difficulty understanding speech in adverse listening
conditions and exhibit degraded temporal resolution, even when audiometric thresholds are …
conditions and exhibit degraded temporal resolution, even when audiometric thresholds are …
Electrophysiological markers of cochlear function correlate with hearing-in-noise performance among audiometrically normal subjects
KJ Grant, AM Mepani, P Wu… - Journal of …, 2020 - journals.physiology.org
Hearing loss caused by noise exposure, ototoxic drugs, or aging results from the loss of
sensory cells, as reflected in audiometric threshold elevation. Animal studies show that loss …
sensory cells, as reflected in audiometric threshold elevation. Animal studies show that loss …
[HTML][HTML] Reliability and interrelations of seven proxy measures of cochlear synaptopathy
Investigations of cochlear synaptopathy in living humans rely on proxy measures of auditory
nerve function. Numerous procedures have been developed, typically based on the auditory …
nerve function. Numerous procedures have been developed, typically based on the auditory …
Synaptopathy in the aging cochlea: Characterizing early-neural deficits in auditory temporal envelope processing
A Parthasarathy, SG Kujawa - Journal of Neuroscience, 2018 - Soc Neuroscience
Aging listeners, even in the absence of overt hearing loss measured as changes in hearing
thresholds, often experience impairments processing temporally complex sounds such as …
thresholds, often experience impairments processing temporally complex sounds such as …
Effects of age and noise exposure on proxy measures of cochlear synaptopathy
Although there is strong histological evidence for age-related synaptopathy in humans,
evidence for the existence of noise-induced cochlear synaptopathy in humans is …
evidence for the existence of noise-induced cochlear synaptopathy in humans is …
The search for noise-induced cochlear synaptopathy in humans: Mission impossible?
N Bramhall, EF Beach, B Epp, CG Le Prell… - Hearing research, 2019 - Elsevier
Animal studies demonstrate that noise exposure can permanently damage the synapses
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …
between inner hair cells and auditory nerve fibers, even when outer hair cells are intact and …