Although fibrosis is a common pathological feature of most end-stage organ diseases, its
pathogenesis remains unclear. There is growing evidence that mitochondrial dysfunction …

Mitochondria are indispensable for energy metabolism and cell signaling. Mitochondrial
homeostasis is sustained with stabilization of mitochondrial membrane potential, balance of …

Mitochondrial dysfunction is a hallmark of many diseases. The retrograde signaling initiated
by dysfunctional mitochondria can bring about global changes in gene expression that alters …

For decades mitochondria have been considered static round-shaped organelles in charge
of energy production. In contrast, they are highly dynamic cellular components that undergo …

Since the first mitochondrial dysfunction was described in the 1960s, the medicine has
advanced in its understanding the role mitochondria play in health, disease, and aging. A …

Mitochondria are the major ATP producer of the mammalian cell. Moreover, mitochondria
are also the main intracellular source and target of reactive oxygen species (ROS) that are …

The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

Mitochondria are subcellular organelles evolved by endosymbiosis of bacteria with
eukaryotic cells characteristics. They are the main source of ATP in the cell and play a …

Mitochondrial functions are intrinsically linked to their morphology and membrane
ultrastructure. Characterizing abnormal mitochondrial structural features may thus provide …

Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …