Endothelial to mesenchymal transition: role in physiology and in the pathogenesis of human diseases

S Piera-Velazquez, SA Jimenez - Physiological reviews, 2019 - journals.physiology.org
Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

The morphological and molecular mechanisms of epithelial/endothelial-to-mesenchymal transition and its involvement in atherosclerosis

M Wesseling, TR Sakkers, SCA De Jager… - Vascular …, 2018 - Elsevier
Cell transdifferentiation occurs during cardiovascular development or remodeling either as a
pathologic feature in the progression of disease or as a response to injury. Endothelial-to …

Endothelial-to-mesenchymal transition: cytokine-mediated pathways that determine endothelial fibrosis under inflammatory conditions

L Pérez, N Muñoz-Durango, CA Riedel… - Cytokine & growth factor …, 2017 - Elsevier
During the last decade, the endothelial-to-mesenchymal transition (EndMT) process has
attracted considerable attention due to associations with the onset of certain diseases, such …

Endothelial to mesenchymal transition in the cardiovascular system

H Gong, X Lyu, Q Wang, M Hu, X Zhang - Life Sciences, 2017 - Elsevier
Endothelial to mesenchymal transition (EndMT) is a special type of epithelial to
mesenchymal transition. It is a process that is characterized by the loss of features of …

Endothelial-to-mesenchymal transition: A novel therapeutic target for cardiovascular diseases

AO Jackson, J Zhang, Z Jiang, K Yin - Trends in Cardiovascular Medicine, 2017 - Elsevier
Endothelial-to-mesenchymal transition (EndMT) is a complex biological process in which
endothelial cells lose their specific markers and acquire a mesenchymal or myofibroblastic …

Endothelial-mesenchymal transition in cardiovascular disease

Z Alvandi, J Bischoff - Arteriosclerosis, thrombosis, and vascular …, 2021 - Am Heart Assoc
Endothelial-to-mesenchymal transition is a dynamic process in which endothelial cells
suppress constituent endothelial properties and take on mesenchymal cell behaviors. To …

The role of endothelial–mesenchymal transition in development and pathological process

F Lin, N Wang, TC Zhang - IUBMB life, 2012 - Wiley Online Library
Epithelial–mesenchymal transition is an important developmental process, participates in
tumor's formation, invasion, and metastasis and has been extensively studied. Recently …

Endothelial to mesenchymal transition: an insight in atherosclerosis

Q Huang, Y Gan, Z Yu, H Wu, Z Zhong - Frontiers in cardiovascular …, 2021 - frontiersin.org
Atherosclerosis is a fundamental disease of the cardiovascular system that leads to high
morbidity and mortality worldwide. The endothelium is the first protective barrier in …

Isoform‐specific effects of transforming growth factor β on endothelial‐to‐mesenchymal transition

H Sabbineni, A Verma… - Journal of cellular …, 2018 - Wiley Online Library
Endothelial‐to‐mesenchymal transition (EndMT) was first reported in the embryogenesis.
Recent studies show that EndMT also occurs in the disease progression of atherosclerosis …

The therapeutic potential of targeting the endothelial-to-mesenchymal transition

S Man, G Sanchez Duffhues, P Ten Dijke, D Baker - Angiogenesis, 2019 - Springer
Endothelial cells (ECs) have been found to be capable of acquiring a mesenchymal
phenotype through a process known as endothelial-to-mesenchymal transition (EndMT) …