AMPK function in mammalian spermatozoa

D Martin-Hidalgo, A Hurtado de Llera… - International journal of …, 2018 - mdpi.com
AMP-activated protein kinase AMPK regulates cellular energy by controlling metabolism
through the inhibition of anabolic pathways and the simultaneous stimulation of catabolic …

AMP-activated kinase AMPK is expressed in boar spermatozoa and regulates motility

A Hurtado de Llera, D Martin-Hidalgo, MC Gil… - PloS one, 2012 - journals.plos.org
The main functions of spermatozoa required for fertilization are dependent on the energy
status and metabolism. AMP-activated kinase, AMPK, acts a sensor and regulator of cell …

[HTML][HTML] AMP-activated kinase, AMPK, is involved in the maintenance of plasma membrane organization in boar spermatozoa

AH De Llera, D Martin-Hidalgo… - … et Biophysica Acta (BBA …, 2013 - Elsevier
Spermatozoa undergo energy-and metabolism-dependent processes to successfully fertilize
the oocyte. AMP-activated protein kinase, AMPK, is a sensor of cell energy. We recently …

AMP-activated kinase in human spermatozoa: identification, intracellular localization, and key function in the regulation of sperm motility

V Calle-Guisado, AH de Llera… - Asian Journal of …, 2017 - journals.lww.com
Abstract AMP-activated kinase (AMPK), a protein that regulates energy balance and
metabolism, has recently been identified in boar spermatozoa where regulates key …

The calcium/CaMKKalpha/beta and the cAMP/PKA pathways are essential upstream regulators of AMPK activity in boar spermatozoa

A Hurtado de Llera, D Martin-Hidalgo… - Biology of …, 2014 - academic.oup.com
Spermatozoa successfully fertilize oocytes depending on cell energy-sensitive processes.
We recently showed that the cell energy sensor, the AMP-activated protein kinase (AMPK) …

Inactivation of AMPKα1 induces asthenozoospermia and alters spermatozoa morphology

P Tartarin, E Guibert, A Touré, C Ouiste… - …, 2012 - academic.oup.com
AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis, is
present in metabolic tissues (muscle and liver) and has been identified as a modulator of the …

Impact of 5'-amp-activated protein kinase on male gonad and spermatozoa functions

TMD Nguyen - Frontiers in Cell and Developmental Biology, 2017 - frontiersin.org
As we already know, the male reproductive system requires less energetic investment than
the female one. Nevertheless, energy balance is an important feature for spermatozoa …

AMPK up-activation reduces motility and regulates other functions of boar spermatozoa

A Hurtado de Llera, D Martin-Hidalgo… - Molecular human …, 2015 - academic.oup.com
We recently demonstrated that AMPK inhibition in spermatozoa regulates motility, plasma
membrane organization, acrosome integrity and mitochondrial membrane potential. As …

[HTML][HTML] 5'-AMP-Activated protein kinase regulates goat sperm functions via energy metabolism in vitro

Z Zhu, R Li, G Ma, W Bai, X Fan, Y Lv, J Luo… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: ATP is essential for mammalian sperm to survive and maintain fertilizing
capacity. AMP-activated protein kinase (AMPK) is a sensor of cellular energy status. The …

Central role of 5′-AMP-activated protein kinase in chicken sperm functions

TMD Nguyen, S Alves, I Grasseau… - Biology of …, 2014 - academic.oup.com
Avian gametes present specific features related to their internal long-term mode of
fertilization. Among other central actors of energetic metabolism control, it has been …