Contribution of the PhoP-PhoQ and PmrA-PmrB Two-Component Regulatory Systems to Mg2+-Induced Gene Regulation in Pseudomonas aeruginosa
When grown in divalent cation-limited medium, Pseudomonas aeruginosa becomes
resistant to cationic antimicrobial peptides and polymyxin B. This resistance is regulated by …
resistant to cationic antimicrobial peptides and polymyxin B. This resistance is regulated by …
Cationic antimicrobial peptides activate a two‐component regulatory system, PmrA‐PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides …
The two‐component regulatory system PhoP‐PhoQ of Pseudomonas aeruginosa regulates
resistance to cationic antimicrobial peptides, polymyxin B and aminoglycosides in response …
resistance to cationic antimicrobial peptides, polymyxin B and aminoglycosides in response …
PhoP–PhoQ homologues in Pseudomonas aeruginosa regulate expression of the outer‐membrane protein OprH and polymyxin B resistance
ELA Macfarlane, A Kwasnicka, MM Ochs… - Molecular …, 1999 - Wiley Online Library
Rapid adaptation to environmental challenge is essential for the survival of many bacterial
species, and is often effectively mediated by two‐component regulatory systems. Part of the …
species, and is often effectively mediated by two‐component regulatory systems. Part of the …
Role of Pseudomonas aeruginosa PhoP-PhoQ in resistance to antimicrobial cationic peptides and aminoglycosides
ELA Macfarlane, A Kwasnicka… - Microbiology, 2000 - microbiologyresearch.org
Resistance to the polycationic antibiotic polymyxin B and expression of the outer-membrane
protein OprH in the opportunistic pathogen Pseudomonas aeruginosa both involve the PhoP …
protein OprH in the opportunistic pathogen Pseudomonas aeruginosa both involve the PhoP …
Polyamines Induce Resistance to Cationic Peptide, Aminoglycoside, and Quinolone Antibiotics in Pseudomonas aeruginosa PAO1
Pseudomonas aeruginosa, a gram-negative bacterium of human pathogens, is noted for its
environmental versatility, enormous metabolic capacity, and resistance to antibiotics …
environmental versatility, enormous metabolic capacity, and resistance to antibiotics …
Regulation of polymyxin resistance and adaptation to low-Mg2+ environments
EA Groisman, J Kayser, FC Soncini - Journal of bacteriology, 1997 - Am Soc Microbiol
The PmrA-PmrB two-component system of Salmonella typhimurium controls resistance to
the peptide antibiotic polymyxin B and to several antimicrobial proteins from human …
the peptide antibiotic polymyxin B and to several antimicrobial proteins from human …
Identification and Molecular Characterization of the Mg2+ Stimulon of Escherichia coli
S Minagawa, H Ogasawara, A Kato… - Journal of …, 2003 - Am Soc Microbiol
Transcription profile microarray analysis in Escherichia coli was performed to identify the
member genes of the Mg2+ stimulon that respond to the availability of external Mg2+ in a …
member genes of the Mg2+ stimulon that respond to the availability of external Mg2+ in a …
Activated by different signals, the PhoP/PhoQ two-component system differentially regulates metal uptake
E Choi, EA Groisman, D Shin - Journal of bacteriology, 2009 - Am Soc Microbiol
ABSTRACT The PhoP/PhoQ two-component system controls several physiological and
virulence functions in Salmonella enterica. This system is activated by low Mg2+, acidic pH …
virulence functions in Salmonella enterica. This system is activated by low Mg2+, acidic pH …
Feedback inhibition in the PhoQ/PhoP signaling system by a membrane peptide
AM Lippa, M Goulian - PLoS genetics, 2009 - journals.plos.org
The PhoQ/PhoP signaling system responds to low magnesium and the presence of certain
cationic antimicrobial peptides. It regulates genes important for growth under these …
cationic antimicrobial peptides. It regulates genes important for growth under these …
Adaptive Resistance to the “Last Hope” Antibiotics Polymyxin B and Colistin in Pseudomonas aeruginosa Is Mediated by the Novel Two-Component Regulatory …
L Fernández, WJ Gooderham, M Bains… - Antimicrobial agents …, 2010 - Am Soc Microbiol
As multidrug resistance increases alarmingly, polymyxin B and colistin are increasingly
being used in the clinic to treat serious Pseudomonas aeruginosa infections. In this …
being used in the clinic to treat serious Pseudomonas aeruginosa infections. In this …