Partial restoration of cardiovascular function by embryonic neural stem cell grafts after complete spinal cord transection

S Hou, VJ Tom, L Graham, P Lu… - Journal of …, 2013 - Soc Neuroscience
High-level spinal cord injury can lead to cardiovascular dysfunction, including disordered
hemodynamics at rest and autonomic dysreflexia during noxious stimulation. To restore …

Grafting embryonic raphe neurons reestablishes serotonergic regulation of sympathetic activity to improve cardiovascular function after spinal cord injury

S Hou, TM Saltos, E Mironets… - Journal of …, 2020 - Soc Neuroscience
Cardiovascular dysfunction often occurs after high-level spinal cord injury. Disrupting
supraspinal vasomotor pathways affects basal hemodynamics and contributes to the …

Characterization of supraspinal vasomotor pathways and autonomic dysreflexia after spinal cord injury in F344 rats

S Hou, P Lu, A Blesch - Autonomic neuroscience, 2013 - Elsevier
Cardiovascular dysfunction usually occurs after high thoracic and cervical spinal cord injury
(SCI). The disruption of supraspinal vasomotor pathways (SVPs) results in the loss of …

Structural neuroplasticity following T5 spinal cord transection: increased cardiac sympathetic innervation density and SPN arborization

HL Lujan, G Palani, SE DiCarlo - American Journal of …, 2010 - journals.physiology.org
When the spinal cord is injured at or below thoracic level 5 (T5), cardiovascular control is
markedly unbalanced as the heart and blood vessels innervated by upper thoracic …

Autonomic dysreflexia: a cardiovascular disorder following spinal cord injury

H Sharif, S Hou - Neural regeneration research, 2017 - journals.lww.com
Autonomic dysreflexia (AD) is a serious cardiovascular disorder in patients with spinal cord
injury (SCI). The primary underlying cause of AD is loss of supraspinal control over …

Changes in the morphology of sympathetic preganglionic neurons parallel the development of autonomic dysreflexia after spinal cord injury in rats

NR Krenz, LC Weaver - Neuroscience letters, 1998 - Elsevier
Following spinal cord transection (SCT), sensory input to the spinal cord causes increases in
arterial pressure that are small in rats 1 week after SCT, but become large and well …

Olfactory ensheathing cells reduce duration of autonomic dysreflexia in rats with high spinal cord injury

T Kalinčík, EA Choi, F Féron, J Bianco… - Autonomic …, 2010 - Elsevier
Autonomic dysreflexia is a common complication in high spinal cord injury and can result in
serious consequences and death. Here we have examined the effect of acute …

Neuroprotection, plasticity manipulation, and regenerative strategies to improve cardiovascular function following spinal cord injury

JW Squair, CR West, AV Krassioukov - Journal of Neurotrauma, 2015 - liebertpub.com
Damage to the central nervous system, as in the case of spinal cord injury (SCI), results in
disrupted supraspinal sympathetic influence and subsequent cardiovascular control …

Effect of graded spinal cord compression on cardiovascular neurons in the rostro-ventro-lateral medulla

AV Krassioukov, MG Fehlings - Neuroscience, 1999 - Elsevier
In patients with spinal cord injury, cardiovascular disturbances such as hypotension,
bradycardia and autonomic dysreflexia can be directly linked to abnormalities of central …

Survival and differentiation of human embryonic stem cell-derived neural precursors grafted spinally in spinal ischemia-injured rats or in naive immunosuppressed …

O Kakinohana, J Juhasova, S Juhas… - Cell …, 2012 - journals.sagepub.com
In previous studies, we have demonstrated that spinal grafting of human or rat fetal spinal
neural precursors leads to amelioration of spasticity and improvement in ambulatory function …