Doxorubicin-mediated cardiac dysfunction: Revisiting molecular interactions, pharmacological compounds and (nano) theranostic platforms

X Li - Environmental Research, 2023 - Elsevier
Although chemotherapy drugs are extensively utilized in cancer therapy, their administration
for treatment of patients has faced problems that regardless of chemoresistance, increasing …

Insights into doxorubicin-induced cardiotoxicity: molecular mechanisms, preventive strategies, and early monitoring

N Wenningmann, M Knapp, A Ande, TR Vaidya… - Molecular …, 2019 - ASPET
Doxorubicin (DOX) is one of the most effective anticancer drugs to treat various forms of
cancers; however, its therapeutic utility is severely limited by its associated cardiotoxicity …

[HTML][HTML] Role of Oxidative Stress and Inflammation in Doxorubicin-Induced Cardiotoxicity: A Brief Account

R Vitale, S Marzocco, A Popolo - International Journal of Molecular …, 2024 - mdpi.com
Cardiotoxicity is the main side effect of several chemotherapeutic drugs. Doxorubicin (Doxo)
is one of the most used anthracyclines in the treatment of many tumors, but the development …

Doxorubicin-induced cardiotoxicity and cardioprotective agents: classic and new players in the game

F dos Santos Arruda, FD Tomé… - Current …, 2019 - ingentaconnect.com
Doxorubicin (DOX) is a cytostatic antibiotic from the class of anthracyclines widely used in
chemotherapeutic cancer treatments. Despite the efficiency against several types of cancer …

Toxic effects and molecular mechanism of doxorubicin on different organs–an update

K Renu, LP Pureti, B Vellingiri… - Toxin …, 2022 - Taylor & Francis
Doxorubicin is an extensively used anti-neoplastic drug used for solid and hematogenous
cancer since the 1950s, and its usage is limited due to its toxic effects upon various organs …

[HTML][HTML] Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management

PS Rawat, A Jaiswal, A Khurana, JS Bhatti… - Biomedicine & …, 2021 - Elsevier
Doxorubicin (Dox) is a secondary metabolite of the mutated strain of Streptomyces peucetius
var. Caesius and belongs to the anthracyclines family. The anti-cancer activity of Dox is …

[PDF][PDF] Anti-cancer drug doxorubicin induced cardiotoxicity: Understanding the mechanisms involved in ros generation resulting in mitochondrial dysfunction

S Upadhayay, N Sharma, AK Mantha… - Rasayan J …, 2020 - rasayanjournal.co.in
Doxorubicin (DOX), despite being an effective anti-cancer drug has offsite targets that affect
the vital organs such as heart, brain and kidney. DOX-induced cardiotoxicity is reported as a …

[HTML][HTML] Underlying the mechanisms of doxorubicin-induced acute cardiotoxicity: oxidative stress and cell death

CY Kong, Z Guo, P Song, X Zhang… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Cancer is a destructive disease that causes high levels of morbidity and mortality.
Doxorubicin (DOX) is a highly efficient antineoplastic chemotherapeutic drug, but its use …

Recent progress in doxorubicin-induced cardiotoxicity and protective potential of natural products

J Yu, C Wang, Q Kong, X Wu, JJ Lu, X Chen - Phytomedicine, 2018 - Elsevier
Background As an anthracycline antibiotic, doxorubicin (DOX) is one of the most potent and
widely used chemotherapeutic agents for various types of solid tumors. Unfortunately …

Novel molecular mechanisms of doxorubicin cardiotoxicity: latest leading-edge advances and clinical implications

Y Robert Li, K Traore, H Zhu - Molecular and Cellular Biochemistry, 2023 - Springer
Doxorubicin (Dox) is among the most widely used cancer chemotherapeutic drugs. The
clinical use of Dox is, however, limited due to its cardiotoxicity. Studies over the past several …