Therapeutic RNA molecules possess high potential for treating medical conditions if they
can successfully reach the target cell upon administration. However, unmodified RNA …

Abstract 12 years following the discovery of the RNAi mechanism in Man, a number of RNAi
therapeutics development candidates have emerged with profiles suggesting that they could …

RNA therapy refers to the treatment or prevention of diseases using RNA-based molecules.
The recent advent of a series of effective messenger RNA-based vaccines in response to the …

RNA therapeutics (eg siRNA, oligonucleotides, mRNA, etc.) show great potential for the
treatment of a myriad of diseases. However, to reach their site of action in the cytosol or …

RNA-based gene therapy requires therapeutic RNA to function inside target cells without
eliciting unwanted immune responses. RNA can be ferried into cells using non-viral drug …

Recent advances in the generation, purification and cellular delivery of RNA have enabled
development of RNA-based therapeutics for a broad array of applications. RNA therapeutics …

Recently, there have been significant advances in the field of RNA‐based therapeutics
harnessing exogenous RNAs including small interfering RNA (siRNA), microRNA (miRNA) …

Long-term research on various types of RNAs has led to further understanding of diverse
mechanisms, which eventually resulted in the rapid development of RNA-based …

Though therapeutics based on messenger RNA (mRNA) have broad potential in
applications such as protein replacement therapy, cancer immunotherapy, and genomic …

Small-molecule and protein/antibody drugs mainly act on genome-derived proteins to exert
pharmacological effects. RNA based therapies hold the promise to expand the range of …