Although virus–host interactions are usually studied in a single cell type using in vitro assays
in immortalized cell lines or isolated cell populations, it is important to remember that what is …

Deciphering the many interactions that occur between a virus and host cell over the course
of infection is paramount to understanding mechanisms of pathogenesis and to the future …

As obligate intracellular parasites, viruses are intimately interconnected with their host cells.
Virus–host cell interactions allow viruses to exploit cells for their own purposes, but they also …

Systems biology and the host response to viral infection | Nature Biotechnology Skip to main
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Research embracing systems biology approaches and careful analysis of the critical host
response has greatly expanded our understanding of infectious diseases. First-generation …

Abstract The Systems Biology for Infectious Diseases Research program was established by
the US National Institute of Allergy and Infectious Diseases to investigate host-pathogen …

Humans and animals are infected by multiple endogenous and exogenous viruses but few
agents cause overt tissue damage. We review the circumstances which favor overt disease …

The outcome of viral infection depends on the interplay between host factors and the
environment. Host factors, like the expression of viral receptors, convey permissiveness to …

Viruses rely on host cell machinery for successful infection, while at the same time evading
the host immune response. Characterization of these processes has revealed insights both …

Viruses are obligate intracellular parasites of the host cells. A commonly accepted view is
the requirement of internal membranous structures for various aspects of viral life cycle …