The measurement of DNA adducts, the covalent modifications of DNA upon the exposure to
the environmental and dietary genotoxicants and endogenously produced electrophiles …

Systems toxicology is a broad-based approach to describe many of the toxicological
features that occur within a living system under stress or subjected to exogenous or …

Mass spectrometry-based DNA adductomics is an emerging approach for the human
biomonitoring of hazardous chemicals. A mass spectral database of DNA adducts will be …

DNA adducts can be induced by both endogenous and external sources. Qualitative and
quantitative characterizations of DNA adducts are crucial to understanding their roles in the …

The exposure of human DNA to genotoxic compounds induces the formation of covalent
DNA adducts, which may contribute to the initiation of carcinogenesis. Liquid …

Exposure to endogenous and exogenous factors can result in the formation of a wide variety
of DNA adducts, and these may lead to gene mutations, thereby contributing to the …

Frequent exposure to chemicals in the environment, diet, and endogenous electrophiles
leads to chemical modification of DNA and the formation of DNA adducts. Some DNA …

Endogenous electrophiles, ionizing and non-ionizing radiation, and hazardous chemicals
present in the environment and diet can damage DNA by forming covalent adducts. DNA …

Adductomics is expected to be useful in the characterization of the exposome, which is a
new paradigm for studying the sum of environmental causes of diseases. DNA adductomics …

Covalent modification of DNA, resulting in the formation of DNA adducts, plays a central role
in chemical carcinogenesis. Investigating these modifications is of fundamental importance …