The pathogenesis, epidemiology and management of glucocorticoid-induced osteoporosis

TP Van Staa - Calcified tissue international, 2006 - Springer
Oral glucocorticoids (GCs) are frequently used in the treatment of inflammatory conditions,
such as rheumatoid arthritis or asthma. They have adverse skeletal effects, primarily through …

Glucocorticoid-induced osteoporosis: pathogenesis and management

J Nishimura, S Ikuyama - Journal of bone and mineral metabolism, 2000 - Springer
Abstract Glucocorticoid-(GC-) induced osteoporosis and an increased risk of fractures are
one of the most serious problems for patient using long-term GC therapy, such as those with …

Oral glucocorticoid use is associated with an increased risk of fracture

M Steinbuch, TE Youket, S Cohen - Osteoporosis international, 2004 - Springer
Oral glucocorticoids (GCs) are widely used and despite their adverse effects on bone
mineral density, the risk of sustaining osteoporotic fractures is not well addressed. The …

Adverse effects of corticosteroids on bone metabolism: a review

R Mitra - PM&R, 2011 - Elsevier
Glucocorticoid (GC) exposure is the most common etiology of drug-induced (secondary)
osteoporosis. Twenty percent of all cases of osteoporosis have been attributed to GC …

Pathogenesis of glucocorticoid-induced osteoporosis and options for treatment

P Chotiyarnwong, EV McCloskey - Nature Reviews Endocrinology, 2020 - nature.com
Glucocorticoids are widely used to suppress inflammation or the immune system. High
doses and long-term use of glucocorticoids lead to an important and common iatrogenic …

Glucocorticoid-induced osteoporosis

IR Reid - Best Practice & Research Clinical Endocrinology & …, 2000 - Elsevier
Glucocorticoid drugs interact with bone metabolism at many levels, but their principal action
is to reduce osteoblast number and bone matrix synthesis. Virtually all patients receiving …

Glucocorticoid-induced osteoporosis

L Buckley, MB Humphrey - New England Journal of Medicine, 2018 - Mass Medical Soc
Key Clinical Points Glucocorticoid-Induced Osteoporosis Risk factors for glucocorticoid-
induced fractures include age (> 55 years), female sex, white race, and long-term use of …

Glucocorticoid‐induced bone disease

RS Weinstein - Primer on the metabolic bone diseases and …, 2013 - Wiley Online Library
Glucocorticoid‐induced osteoporosis (GIO) is the second most common form of osteoporosis
and is the most common iatrogenic form of the disease. Fractures may occur in 30% to 50 …

Glucocorticoid-induced osteoporosis

KG Saag - Endocrinology and Metabolism Clinics, 2003 - endo.theclinics.com
Therapeutic use of glucocorticoids can lead to many well-known adverse events [1]. Of all
potential serious side effects, glucocorticoid-induced osteoporosis (GIOP) is one of the most …

Use of oral corticosteroids and risk of fractures

TP Van Staa, HGM Leufkens… - Journal of bone and …, 2000 - Wiley Online Library
Abstract Treatment with oral corticosteroids is known to decrease bone density but there are
few data on the attendant risk of fracture and on the reversibility of this risk after cessation of …