Sarcopenia is a cause and consequence of metabolic dysregulation in aging humans: effects of gut dysbiosis, glucose dysregulation, diet and lifestyle

JW Daily, S Park - Cells, 2022 - mdpi.com
Skeletal muscle mass plays a critical role in a healthy lifespan by helping to regulate
glucose homeostasis. As seen in sarcopenia, decreased skeletal muscle mass impairs …

Mechanisms linking the gut-muscle axis with muscle protein metabolism and anabolic resistance: implications for older adults at risk of sarcopenia

K Prokopidis, E Chambers, M Ni Lochlainn… - Frontiers in …, 2021 - frontiersin.org
Aging is associated with a decline in skeletal muscle mass and function—termed sarcopenia—
as mediated, in part, by muscle anabolic resistance. This metabolic phenomenon describes …

Aging gut microbiota at the cross-road between nutrition, physical frailty, and sarcopenia: is there a gut–muscle axis?

A Ticinesi, F Lauretani, C Milani, A Nouvenne, C Tana… - Nutrients, 2017 - mdpi.com
Inadequate nutrition and physical inactivity are the mainstays of primary sarcopenia–
physiopathology in older individuals. Gut microbiota composition is strongly dependent on …

Understanding the gut microbiota and sarcopenia: a systematic review

C Liu, WH Cheung, J Li, SKH Chow… - Journal of cachexia …, 2021 - Wiley Online Library
Background Gut microbiota dysbiosis and sarcopenia commonly occur in the elderly.
Although the concept of the gut–muscle axis has been raised, the casual relationship is still …

Gut dysbiosis and muscle aging: searching for novel targets against sarcopenia

A Picca, F Fanelli, R Calvani, G Mulè… - Mediators of …, 2018 - Wiley Online Library
Advanced age is characterized by several changes, one of which is the impairment of the
homeostasis of intestinal microbiota. These alterations critically influence host health and …

Gut microbiota as a promising therapeutic target for age-related sarcopenia

T Zhang, J Cheng, Y Hu - Ageing research reviews, 2022 - Elsevier
Sarcopenia is characterized by a progressive loss of skeletal muscle mass and function with
aging. Recently, sarcopenia has been shown to be closely related with gut microbiota …

Gut microbiota, muscle mass and function in aging: a focus on physical frailty and sarcopenia

A Ticinesi, A Nouvenne, N Cerundolo, P Catania… - Nutrients, 2019 - mdpi.com
Human gut microbiota is able to influence the host physiology by regulating multiple
processes, including nutrient absorption, inflammation, oxidative stress, immune function …

A narrative review of gut-muscle axis and sarcopenia: The potential role of gut microbiota

J Zhao, Y Huang, X Yu - International Journal of General Medicine, 2021 - Taylor & Francis
Sarcopenia is a multifactorial disease related to aging, chronic inflammation, insufficient
nutrition, and physical inactivity. Previous studies have suggested that there is a relationship …

Impact of protein intake in older adults with sarcopenia and obesity: a gut microbiota perspective

K Prokopidis, MM Cervo, A Gandham, D Scott - Nutrients, 2020 - mdpi.com
The continuous population increase of older adults with metabolic diseases may contribute
to increased prevalence of sarcopenia and obesity and requires advocacy of optimal …

Multifactorial mechanism of sarcopenia and sarcopenic obesity. Role of physical exercise, microbiota and myokines

J Bilski, P Pierzchalski, M Szczepanik, J Bonior… - Cells, 2022 - mdpi.com
Obesity and ageing place a tremendous strain on the global healthcare system. Age-related
sarcopenia is characterized by decreased muscular strength, decreased muscle quantity …