With the appearance of the antifungal resistance, novel antifungal agents need to be
identified. In this context new 2, 5-disubstituted tetrazole derivatives containing …

The increase of opportunistic fungal infections raises the need for design and synthesis of
new antifungal agents. Taking into account that tetrazole derivatives exhibit antifungal …

In an effort to develop novel azole antifungals with potent activity and high selectivity, a
series of (2R, 3R)-3-((3-substitutied-phenyl-isoxazol-5-yl) methoxy)-2-(2, 4-difluorophenyl)-1 …

A series of novel tetrazole derivatives was synthetized using N-alkylation or Michael-type
addition reactions, and screened for their fungistatic potential against Candida albicans (the …

Several 5-thio-substituted tetrazole derivatives were efficiently synthesized by a three-step
process. The substituted tetrazol-5-thiol, namely, 1-benzyl-1H-tetrazol-5-thiol (2) was …

In an effort to find potent antifungal agents, a variety of triazole derivatives with a 5-
substituted tetrazole structure 6, 7, 12 and 14 were prepared and evaluated for antifungal …

In pursuit of developing novel azole antifungals with potent activity and high selectivity, a
series of (2 R, 3 S)-3-(substituted-1 H-pyrazol-3-yl)-2-(2, 4-difluorophenyl)-1-(1 H-tetrazol-1 …

Objective: Antimicrobials and antifungals are the most acquired drugs in the world. Today, it
becomes necessary to create new drugs with antimicrobial and antifungal effect. The …

A new series of 1, 2, 4-triazoles containing cyclopropane moiety were synthesized and
characterized by 1H NMR and elemental analyses. The biological activities results showed …

In search of potent and safe antifungal agents, herein, we report the synthesis,
characterization and biological activities of triazole-oxadiazole compounds. The structural …