Pyroptosis, and its role in central nervous system disease

Y Hu, B Wang, S Li, S Yang - Journal of molecular biology, 2022 - Elsevier
Pyroptosis is an inflammatory form of cell death executed by transmembrane pore-forming
proteins known as gasdermins and can be activated in an inflammasome-dependent or …

Fiery cell death: pyroptosis in the central nervous system

BA McKenzie, VM Dixit, C Power - Trends in neurosciences, 2020 - cell.com
Pyroptosis ('fiery death') is an inflammatory type of regulated cell death (RCD), which occurs
downstream of inflammasome activation. Pyroptosis is mediated directly by the recently …

Role of pyroptosis in the pathogenesis of various neurological diseases

A Oladapo, T Jackson, J Menolascino… - Brain, Behavior, and …, 2024 - Elsevier
Pyroptosis, an inflammatory programmed cell death process, has recently garnered
significant attention due to its pivotal role in various neurological diseases. This review …

Research progress of pyroptosis in alzheimer's disease

W Xue, D Cui, Y Qiu - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is a disease characterized by insidious and progressive
neurodegeneration, with clinical syndromes of memory and visuospatial skills damage. The …

Mechanism of pyroptosis in neurodegenerative diseases and its therapeutic potential by traditional Chinese medicine

Y Liao, X Wang, L Huang, H Qian, W Liu - Frontiers in Pharmacology, 2023 - frontiersin.org
Neurodegenerative diseases (NDs) are disorders characterized by degenerative
degeneration of neurons and loss of their function. NDs have a complicated …

The role of pyroptosis in inflammatory diseases

R Chai, Y Li, L Shui, L Ni, A Zhang - Frontiers in Cell and …, 2023 - frontiersin.org
Programmed cell death has crucial roles in the physiological maturation of an organism, the
maintenance of metabolism, and disease progression. Pyroptosis, a form of programmed …

Targeting pyroptosis to regulate ischemic stroke injury: molecular mechanisms and preclinical evidences

A Ye, W Li, L Zhou, L Ao, W Fang, Y Li - Brain Research Bulletin, 2020 - Elsevier
Stroke is one of the leading causes of death worldwide with limited therapies. After ischemic
stroke occurs, a robust sterile inflammatory response happens and lasts for days and …

Pyroptosis: a promising therapeutic target for noninfectious diseases

T Li, G Zheng, B Li, L Tang - Cell proliferation, 2021 - Wiley Online Library
Pyroptosis, which is characterized by gasdermin family protein‐mediated pore formation,
cellular lysis and the release of pro‐inflammatory cytokines, is a form of programmed cell …

Role of pyroptosis in inflammation and cancer

X Wei, F Xie, X Zhou, Y Wu, H Yan, T Liu… - Cellular & molecular …, 2022 - nature.com
Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …

Pyroptosis in spinal cord injury

J Yin, G Gong, W Wan, X Liu - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Spinal cord injury (SCI) often brings devastating consequences to patients and their families.
Pathophysiologically, the primary insult causes irreversible damage to neurons and glial …