The leukodystrophies are a group of inherited white matter disorders with a heterogeneous
genetic background, considerable phenotypic variability and disease onset at all ages. This …

Background: The leukodystrophies are a heterogeneous group of diseases, which primarily
affect white matter. Symptomatic patients are frequently misdiagnosed and the …

Introduction: Leukodystrophies constitute heterogenous group of rare heritable disorders
primarily affecting the white matter of central nervous system. These conditions are often …

Better understanding of leukodystrophies in neurological routine practice is of crucial
importance for differentiating between other white matter diseases such as toxic …

Leukodystrophies are genetically determined disorders characterized by the selective
involvement of the central nervous system white matter. Onset may be at any age, from …

Leukodystrophies were defined in the 1980s as progressive genetic disorders primarily
affecting myelin of the central nervous system. At that time, a limited number of such …

Adult-onset leukodystrophies and genetic leukoencephalopathies comprise a diverse group
of neurodegenerative disorders of white matter with a wide age of onset and phenotypic …

Leukodystrophies are white matter disorders that are genetic in nature. In the young, they
represent an important cause of progressive neurological disability. They are frequently …

Leukodystrophies comprise a large group of rare genetic disorders primarily affecting CNS
white matter. Historically, the diagnostic process was slow and patient prognosis regarded …

Leukodystrophies usually affect children, but in the last several decades, many instances of
adult leukodystrophies have been reported in the medical literature. Because the clinical …