[HTML][HTML] The blood–brain barrier in health and disease: Important unanswered questions

CP Profaci, RN Munji, RS Pulido… - Journal of Experimental …, 2020 - rupress.org
The blood vessels vascularizing the central nervous system exhibit a series of distinct
properties that tightly control the movement of ions, molecules, and cells between the blood …

The blood–brain barrier—gatekeeper to neuronal homeostasis: clinical implications in the setting of stroke

K Schoknecht, Y David, U Heinemann - Seminars in cell & developmental …, 2015 - Elsevier
The blood–brain barrier is part of the neurovascular unit and serves as a functional and
anatomical barrier between the blood and the extracellular space. It controls the flow of …

The blood–brain barrier

R Daneman, A Prat - Cold Spring Harbor perspectives in …, 2015 - cshperspectives.cshlp.org
Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs
throughout the body. The blood vessels that vascularize the central nervous system (CNS) …

The blood-brain barrier in health and chronic neurodegenerative disorders

BV Zlokovic - Neuron, 2008 - cell.com
The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully
differentiated neurovascular system. In concert with pericytes, astrocytes, and microglia, the …

The blood–brain barrier in health and disease

R Daneman - Annals of neurology, 2012 - Wiley Online Library
The blood–brain barrier (BBB) is a term used to describe a series of properties possessed
by the vasculature of the central nervous system (CNS) that tightly regulate the movement of …

Blood-brain barrier: more contributor to disruption of central nervous system homeostasis than victim in neurological disorders

M Xiao, ZJ Xiao, B Yang, Z Lan, F Fang - Frontiers in Neuroscience, 2020 - frontiersin.org
The blood-brain barrier (BBB) is a dynamic but solid shield in the cerebral microvascular
system. It plays a pivotal role in maintaining central nervous system (CNS) homeostasis by …

Engaging neuroscience to advance translational research in brain barrier biology

EA Neuwelt, B Bauer, C Fahlke, G Fricker… - Nature Reviews …, 2011 - nature.com
The delivery of many potentially therapeutic and diagnostic compounds to specific areas of
the brain is restricted by brain barriers, of which the most well known are the blood–brain …

The blood–brain barrier

B Obermeier, A Verma, RM Ransohoff - Handbook of clinical neurology, 2016 - Elsevier
In autoimmune neurologic disorders, the blood–brain barrier (BBB) plays a central role in
immunopathogenesis, since this vascular interface is an entry path for cells and effector …

The role of the blood–brain barrier during neurological disease and infection

A Patabendige, D Janigro - Biochemical Society Transactions, 2023 - portlandpress.com
A healthy brain is protected by the blood–brain barrier (BBB), which is formed by the
endothelial cells that line brain capillaries. The BBB plays an extremely important role in …

[HTML][HTML] Blood-brain barrier: from physiology to disease and back

MD Sweeney, Z Zhao, A Montagne… - Physiological …, 2018 - journals.physiology.org
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …