Abstract Interferon-α2b (IFN-α2b) is a highly active cytokine that belongs to the interferon-α
(IFN-α) family. IFN-α2b has beneficial antiviral, antitumour, antiparasitic and …

During the last decades, the pleiotropic antitumor functions exerted by type I interferons
(IFNs) have become universally acknowledged, especially their role in mediating …

The clinical possibilities of interferon (IFN) became apparent with early studies
demonstrating that it was capable of inhibiting tumor cells in culture and in vivo using animal …

Interferon (IFN)-γ is the uppermost cytokine implicated in anti-tumor immunity. With its
cytostatic, pro-apoptotic and immune-provoking effects, IFN-γ plays a central role in the …

Interferons-α (IFN-α) are pleiotropic cytokines belonging to type I IFNs, extensively used in
the treatment of patients with some types of cancer and viral disease. IFN-α can affect tumor …

Purpose: Antiproliferative, antiviral, and immunomodulatory activities of endogenous type I
IFNs (IFN1) prompt the design of recombinant IFN1 for therapeutic purposes. However, most …

Interferon-γ is a cytokine whose biological activity is conventionally associated with
cytostatic/cytotoxic and antitumor mechanisms during cell-mediated adaptive immune …

IFN-γ, a soluble cytokine being produced by T lymphocytes, macrophages, mucosal
epithelial cells, or natural killer cells, is able to bind to the IFN-γ receptor (IFNγR) and in turn …

A number of tumors are still resistant to the antiproliferative activity of human interferon (IFN)-
α. The Janus kinases/Signal Transducers and Activators of Transcription (JAK-STAT) …

Interferon-α (IFN-α) is currently the most used cytokine in the treatment of cancer. However,
the potential anti-tumour activity of IFN-α is limited by the activation of tumour resistance …