Emergence of protein kinase CK2 as a key target in cancer therapy
JH Trembley, Z Chen, G Unger, J Slaton, BT Kren… - Biofactors, 2010 - Wiley Online Library
Protein kinase CK2, a protein serine/threonine kinase, plays a global role in activities related
to cell growth, cell death, and cell survival. CK2 has a large number of potential substrates …
to cell growth, cell death, and cell survival. CK2 has a large number of potential substrates …
[HTML][HTML] Protein kinase CK2–diverse roles in cancer cell biology and therapeutic promise
JH Trembley, BT Kren, M Afzal, GA Scaria… - Molecular and cellular …, 2023 - Springer
The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …
Protein kinase CK2 in health and disease: CK2: a key player in cancer biology
JH Trembley, G Wang, G Unger, J Slaton… - Cellular and molecular …, 2009 - Springer
Elevated levels of protein kinase CK2 (formerly casein kinase 2 or II) have long been
associated with increased cell growth and proliferation both in normal and cancer cells. The …
associated with increased cell growth and proliferation both in normal and cancer cells. The …
Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2
JS Duncan, DW Litchfield - Biochimica et Biophysica Acta (BBA)-Proteins …, 2008 - Elsevier
CK2 is a highly conserved protein serine/threonine kinase that is ubiquitously distributed in
eukaryotes, constitutively active and has been implicated in multiple cellular functions, as …
eukaryotes, constitutively active and has been implicated in multiple cellular functions, as …
Protein kinase CK2 as regulator of cell survival: implications for cancer therapy
GM Unger, AT Davis, JW Slaton… - Current cancer drug …, 2004 - ingentaconnect.com
Recent studies have generated sufficient information to warrant a consideration of protein
kinase CK2 as a potential target for cancer therapy. CK2 is a ubiquitous and highly …
kinase CK2 as a potential target for cancer therapy. CK2 is a ubiquitous and highly …
Protein kinase CK2 is a constitutively active enzyme that promotes cell survival: strategies to identify CK2 substrates and manipulate its activity in mammalian cells
JP Turowec, JS Duncan, AC French, L Gyenis… - Methods in …, 2010 - Elsevier
Protein kinase CK2 is a constitutively active protein serine/threonine kinase that is
ubiquitously expressed and essential for the survival of eukaryotic cells. On the basis of its …
ubiquitously expressed and essential for the survival of eukaryotic cells. On the basis of its …
Protein kinase CK2 as a druggable target
CK2 is probably the most pleiotropic Ser/Thr protein kinase with hundreds of endogenous
substrates already known, which are implicated in a variety of cellular functions. At variance …
substrates already known, which are implicated in a variety of cellular functions. At variance …
[HTML][HTML] CK2 in cancer: cellular and biochemical mechanisms and potential therapeutic target
MMJ Chua, CE Ortega, A Sheikh, M Lee… - Pharmaceuticals, 2017 - mdpi.com
CK2 genes are overexpressed in many human cancers, and most often overexpression is
associated with worse prognosis. Site-specific expression in mice leads to cancer …
associated with worse prognosis. Site-specific expression in mice leads to cancer …
Protein kinase CK2 in human diseases
B Guerra, OG Issinger - Current medicinal chemistry, 2008 - ingentaconnect.com
Protein kinase CK2 (formerly referred to as casein kinase II) is an evolutionary conserved,
ubiquitous protein kinase. There are two paralog catalytic subunits, ie alpha (A1) and …
ubiquitous protein kinase. There are two paralog catalytic subunits, ie alpha (A1) and …
Phosphorylation regulates the stability of the regulatory CK2β subunit
C Zhang, G Vilk, DA Canton, DW Litchfield - Oncogene, 2002 - nature.com
Protein kinase CK2 is a protein serine/threonine kinase that exhibits elevated expression in
a number of cancers and displays oncogenic activity in mice. The regulatory CK2β subunit …
a number of cancers and displays oncogenic activity in mice. The regulatory CK2β subunit …