Epigenetic modifications occur sequentially during the lifespan, but their pace can be altered
by external stimuli. The onset of schizophrenia and bipolar disorder is critically modulated by …

Bipolar disorder (BD) and schizophrenia (SCZ) are debilitating disorders that are associated
with significant burden and reduced quality of life. In this study, we leveraged microarray …

Bipolar disorder (BD) is a chronic and severe psychiatric disorder associated with significant
medical morbidity and reduced life expectancy. In this study, we assessed accelerated …

Bipolar disorder (BD) has been previously associated with accelerated aging; yet, the
mechanisms underlying this association are largely unknown. The epigenetic clock has …

Background Major depressive disorder (MDD) is a severe, heritable psychiatric disorder
associated with shortened lifespan and comorbidities of advancing age. It is unknown …

Objectives Exposure to adversity has been linked to accelerated biological aging, which in
turn has been shown to predict numerous physical and mental health problems. In recent …

Schizophrenia is a serious neuropsychiatric disorder with abnormal age-related
neurodevelopmental (or neurodegenerative) trajectories. Although an accelerated aging …

Different psychiatric disorders as well as exposure to adverse life events have individually
been associated with multiple age-related diseases and mortality. Age acceleration in …

Accelerated epigenetic aging relative to chronological age has been found to be associated
with higher risk of mortality in adults. However, little is known about whether and how in …

Background Studies reporting accelerated ageing in children with affective disorders or
maltreatment exposure have relied on algorithms for estimating epigenetic age derived from …