Peripheral artery disease (PAD) is a vascular disorder caused by occlusive atherosclerosis,
which commonly impairs blood flow to the lower extremities. The prevalence of PAD is …

Peripheral artery disease (PAD) is a highly prevalent disease, which still has unmet medical
needs. Therapeutic angiogenesis for PAD, achieved by gene therapy, has achieved …

Background—“Therapeutic angiogenesis” seeks to improve perfusion by the growth of new
blood vessels. The Regional Angiogenesis with Vascular Endothelial growth factor (RAVE) …

Patients with peripheral artery disease (PAD) and critical limb ischemia are the main
candidates for limb amputations and have a poor life expectancy. Frequently, these patients …

Peripheral artery disease (PAD) of the lower extremities is a common manifestation of
atherosclerosis that is increasing in global prevalence and in the associated public health …

Background Peripheral arterial disease remains a significant global health burden despite
revolutionary improvements in endovascular techniques over the past decade. The …

Background Peripheral arterial disease (PAD), caused by narrowing of the arteries in the
limbs, is increasing in incidence and prevalence as our population is ageing and as …

Background Critical limb ischemia (CLI) is the extreme manifestation of peripheral artery
disease, a major unmet clinical need for which lower limb amputation is the only option for …

The World Health Organization announced that cardiovascular disease is the number one
cause of death globally, representing 31% of all global deaths. Coronary artery disease …

Background: Beyond pharmacological, endovascular and surgical treatment strategies for
peripheral arterial disease (PAD), therapeutic angiogenesis has been advocated to relieve …