In recent years, our understanding of the epigenetic mechanisms involved in tumor
pathology has improved greatly. DNA and histone modifications, such as methylation …

As many different genetic alterations in chondrosarcoma have been identified, it is of the
utmost importance to classify druggable targets that may improve the prognosis of …

Simple Summary Chondrosarcoma (ChS) is the second most frequently diagnosed
malignant bone tumor of cartilaginous origin and is generally resistant to standard treatment …

Background Chondrosarcomas are malignant tumors of chondrocytes and represent the
second most common type of primary bone tumors. Within the context of normal …

Chondrosarcomas constitute a heterogeneous group of primary bone cancers characterized
by hyaline cartilaginous neoplastic tissue. They are the second most common primary bone …

Simple Summary Chondrosarcoma (CHS) belongs to a broad group of sarcomas and is the
second most frequent malignant bone tumor. Due to its resistance to chemo-and …

Sarcomas are known as a heterogeneous class of cancers arisen in the connective tissues
and demonstrated various histological subtypes including both soft tissue and bone origin …

Chondrosarcomas are the most common malignant tumors of the cartilage, are seen
predominantly in adults, and have varied clinical behavior. The majority of them affect the …

Although some progress has been made in characterizing chondrosarcoma pathogenesis,
its genetic and epigenetic mechanisms are poorly described, and no known effective …

The detection of mutations of isocitrate dehydrogenase 1 and 2 (IDH 1/2) as tumor driver
genes in chondromas and chondrosarcomas more than ten years ago was a first major step …