The trehalose biosynthesis pathway has recently received attention for therapeutic
intervention combating infectious diseases caused by bacteria, helminths or fungi …

The trehalose biosynthetic pathway is of great interest for the development of novel
therapeutics because trehalose is an essential disaccharide in many pathogens but is …

Owing to the key role of trehalose in pathogenic organisms, there has recently been growing
interest in trehalose metabolism for therapeutic purposes. Trehalose-6-phosphate …

Owing to the key role of trehalose in pathogenic organisms, there has recently been growing
interest in trehalose metabolism for therapeutic purposes. Trehalose-6-phosphate …

The opportunistic bacterium Pseudomonas aeruginosa has been recognized as an
important pathogen of clinical relevance and is a leading cause of hospital‐acquired …

We report the functional and structural characterization of trehalose-6-phosphate
phosphatase (TPP), from the Gram-negative bacterium B. pseudomallei that causes …

Trehalose is a disaccharide essential for the survival and virulence of pathogenic fungi. The
biosynthesis of trehalose requires trehalose-6-phosphate synthase, Tps1, and trehalose-6 …

Abstract α, α′‐Trehalose plays roles in the synthesis of several cell wall components
involved in pathogenic mycobacteria virulence. Its absence in mammalian biochemistry …

As opposed to organism-based drug screening approaches, protein-based strategies have
the distinct advantage of providing insights into the molecular mechanisms of chemical …

Trehalose-6-phosphate phosphatase (T6PP) catalyzes the dephosphorylation of trehalose 6-
phosphate (T6P) to the disaccharide trehalose. The enzyme is not present in mammals but …