Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study
MD Spring, JT Lin, JE Manning… - The Lancet Infectious …, 2015 - thelancet.com
Background Dihydroartemisinin-piperaquine has been adopted as first-line artemisinin
combination therapy (ACT) for multidrug-resistant Plasmodium falciparum malaria in …
combination therapy (ACT) for multidrug-resistant Plasmodium falciparum malaria in …
[HTML][HTML] Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective …
RW van der Pluijm, M Imwong, NH Chau… - The Lancet infectious …, 2019 - thelancet.com
Background The emergence and spread of resistance in Plasmodium falciparum malaria to
artemisinin combination therapies in the Greater Mekong subregion poses a major threat to …
artemisinin combination therapies in the Greater Mekong subregion poses a major threat to …
Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study
C Amaratunga, P Lim, S Suon, S Sreng… - The Lancet infectious …, 2016 - thelancet.com
Summary Background Artemisinin resistance in Plasmodium falciparum threatens to reduce
the efficacy of artemisinin combination therapies (ACTs), thus compromising global efforts to …
the efficacy of artemisinin combination therapies (ACTs), thus compromising global efforts to …
Evidence of Plasmodium falciparum malaria multidrug resistance to artemisinin and piperaquine in western Cambodia: dihydroartemisinin-piperaquine open-label …
R Leang, WRJ Taylor, DM Bouth, L Song… - Antimicrobial agents …, 2015 - Am Soc Microbiol
Western Cambodia is recognized as the epicenter of Plasmodium falciparum multidrug
resistance. Recent reports of the efficacy of dihydroartemisinin (DHA)-piperaquine (PP), the …
resistance. Recent reports of the efficacy of dihydroartemisinin (DHA)-piperaquine (PP), the …
[HTML][HTML] Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in …
V Duru, N Khim, R Leang, S Kim, A Domergue… - BMC medicine, 2015 - Springer
Background The declining efficacy of dihydroartemisinin-piperaquine against Plasmodium
falciparum in Cambodia, along with increasing numbers of recrudescent cases, suggests …
falciparum in Cambodia, along with increasing numbers of recrudescent cases, suggests …
[HTML][HTML] A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype–genotype association study
B Witkowski, V Duru, N Khim, LS Ross… - The Lancet Infectious …, 2017 - thelancet.com
Summary Background Western Cambodia is the epicentre of Plasmodium falciparum
multidrug resistance and is facing high rates of dihydroartemisinin–piperaquine treatment …
multidrug resistance and is facing high rates of dihydroartemisinin–piperaquine treatment …
[HTML][HTML] Rapid decline in the susceptibility of Plasmodium falciparum to dihydroartemisinin–piperaquine in the south of Vietnam
NV Thanh, N Thuy-Nhien, NTK Tuyen, NT Tong… - Malaria journal, 2017 - Springer
Abstract Background Artemisinin resistant Plasmodium falciparum has emerged in the
countries of the Greater Mekong sub-region posing a serious threat to global malaria …
countries of the Greater Mekong sub-region posing a serious threat to global malaria …
[HTML][HTML] Genetic markers associated with dihydroartemisinin–piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype–phenotype association …
Background As the prevalence of artemisinin-resistant Plasmodium falciparum malaria
increases in the Greater Mekong subregion, emerging resistance to partner drugs in …
increases in the Greater Mekong subregion, emerging resistance to partner drugs in …
[HTML][HTML] Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia
Background Artemisinin resistance is associated with delayed parasite clearance half-life in
vivo and correlates with ring-stage survival under dihydroartemisinin in vitro. Both …
vivo and correlates with ring-stage survival under dihydroartemisinin in vitro. Both …
[HTML][HTML] Origins of the current outbreak of multidrug-resistant malaria in southeast Asia: a retrospective genetic study
R Amato, RD Pearson, J Almagro-Garcia… - The Lancet Infectious …, 2018 - thelancet.com
Background Antimalarial resistance is rapidly spreading across parts of southeast Asia
where dihydroartemisinin–piperaquine is used as first-line treatment for Plasmodium …
where dihydroartemisinin–piperaquine is used as first-line treatment for Plasmodium …