Disappointing results with the use of exogenous recombinant growth factors in chronic
wounds have redirected the focus to the extracellular matrix (ECM). Newer research has …

Dynamic interactions between growth factors and extracellular matrix (ECM) are integral to
wound healing. These interactions take several forms that may be categorized as direct or …

The extracellular matrix (ECM) is a 3-dimensional structure and an essential component in
all human tissues. It is comprised of varying proteins, including collagens, elastin, and …

Significance: Fibroblasts play a critical role in normal wound healing. Various extracellular
matrix (ECM) components, including collagens, fibrin, fibronectin, proteoglycans …

Background: Wound healing is a process made up of several phases, including hemostasis/
inflammation, proliferation, and scar formation/remodeling. An array of growth factors is …

Significance: Both chronic wounds and excessive scar formation after cutaneous injury
create a formidable clinical problem resulting in considerable morbidity and healthcare …

Wound healing is a complex, dynamic process required for maintaining homeostasis in an
organism. Along with being controlled biochemically, wound healing is also controlled …

The extracellular matrix (ECM) is the largest component of the dermal skin layer and the
synthesis of ECM is a key feature of wound healing, especially when there has been a …

The dermis normally directs all phases of skin wound healing following tissue trauma or
disease. However, in chronic wounds, the dermal matrix is insufficient to stimulate healing …

Significance: Growth factors are very promising molecules for the treatment of skin wounds.
However, their translation to clinical use has been seriously limited, facing issues related to …