An essential overview of the biological role of coronavirus viroporin (envelope protein) is
given, together with the effect of its known inhibitors on the life cycle of coronavirus. A …

The COVID‐19 epidemic is one of the most influential epidemics in history. Understanding
the impact of coronaviruses (CoVs) on host cells is very important for disease treatment. The …

Viroporins are indispensable for viral replication. As intracellular ion channels they disturb
pH gradients of organelles and allow Ca 2+ flux across ER membranes. Viroporins interact …

One major obstacle in designing a successful therapeutic regimen to combat COVID-19
pandemic is the frequent occurrence of mutations in the SARS-CoV-2 resulting in patient to …

Coronaviruses, especially severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2),
present an ongoing threat to human wellbeing. Consequently, elucidation of molecular …

Background SARS-CoV-2 has caused a worldwide pandemic since December 2019 and the
search for pharmaceutical targets against COVID-19 remains an important challenge. Here …

Viroporins are oligomeric, pore forming, viral proteins that play critical roles in the life cycle
of pathogenic viruses. Viroporins like HIV-1 Vpu, Alphavirus 6 K, Influenza M2, HCV p7, and …

Many research teams all over the world focus their research on the SARS-CoV-2, the new
coronavirus that causes the so-called COVID-19 disease. Most of the studies identify the …

Mpro, the main protease of the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), is essential for the viral life cycle. Accordingly, several groups have performed in …

SARS-CoV-2 infection was first isolated in Wuhan in the end of December 2019, since then,
this β-coronavirus has rapidly spread becoming the most important public health concern …