[HTML][HTML] Folic acid ameliorates the declining quality of sodium fluoride-exposed mouse oocytes through the Sirt1/Sod2 pathway

X Lin, B Fu, Y Xiong, S Xu, J Liu, MY Zaky… - Aging and …, 2022 - ncbi.nlm.nih.gov
Excessive sodium fluoride (NaF) intake interferes with reproductive function in humans and
animals; however, strategies to prevent these effects are still underexplored. Here, we …

Sodium fluoride exposure exerts toxic effects on porcine oocyte maturation

S Liang, ZW Nie, M Zhao, YJ Niu, KT Shin, XS Cui - Scientific Reports, 2017 - nature.com
Excessive long-term fluoride intake is associated with several health problems, including
infertility. However, limited information is available on the toxic effects of fluoride exposure …

Sirtuin 3-mediated deacetylation of superoxide dismutase 2 ameliorates sodium fluoride-induced mitochondrial dysfunction in porcine oocytes

XY Qi, JD Yuan, ZY Liu, XQ Jiang, Q Zhang… - Science of the Total …, 2024 - Elsevier
Fluoride exerts detrimental effects on germ cells and increases the infertility rate in women.
Nevertheless, the precise mechanisms behind the developmental abnormalities caused by …

Sodium fluoride induces apoptosis through reactive oxygen species-mediated endoplasmic reticulum stress pathway in Sertoli cells

Y Yang, X Lin, H Huang, D Feng, Y Ba, X Cheng… - Journal of …, 2015 - Elsevier
Excessive fluoride exposure is known to contribute to reproductive system dysfunction,
ultimately leading to pathological damage and apoptosis in cells. Although both oxidative …

Fluoride impairs oocyte maturation and subsequent embryonic development in mice

S Liang, MH Zhao, SA Ock, NH Kim… - Environmental …, 2016 - Wiley Online Library
The damage caused by fluorosis is permanent, and has been recognized as a public health
problem in a number of regions of the world. Although multiple studies provided evidence …

Fluoride-induced oxidative stress and apoptosis are involved in the reducing of oocytes development potential in mice

HW Wang, WP Zhao, J Liu, PP Tan, C Zhang, BH Zhou - Chemosphere, 2017 - Elsevier
The present study was conducted to investigate the mechanisms of excessive-fluoride-
induced reduction of oocyte development potential in mice. The development morphology of …

Vitamin C attenuates sodium fluoride-induced mitochondrial oxidative stress and apoptosis via Sirt1-SOD2 pathway in F9 cells

W Peng, S Xu, J Zhang, Y Zhang - Biological trace element research, 2019 - Springer
Increasing evidence has suggested an important role played by reactive oxygen species
(ROS) in the pathogenesis of fluorosis. Accumulating evidence demonstrates that vitamin C …

JNK/STAT signalling pathway is involved in fluoride-induced follicular developmental dysplasia in female mice

WP Zhao, HW Wang, J Liu, PP Tan, L Lin, BH Zhou - Chemosphere, 2018 - Elsevier
Excessive fluoride (F) intake decreases the development of potential oocytes by inducing
oxidative stress and apoptosis in female mice in our previous study. This study aims to …

Chronic fluoride exposure induces ovarian dysfunction and Potential Association with premature ovarian failure in female rats

X Tang, H Li, Y Wang, L Zeng, L Long, Y Qu… - … Trace Element Research, 2024 - Springer
Chronic fluorosis has been widely investigated for its adverse effects on skeletal and
neurological health; however, its impact on reproductive health, especially in females …

Toxic effects of sodium fluoride on cell proliferation and apoptosis of Leydig cells from young mice

GH Song, RL Wang, ZY Chen, B Zhang… - Journal of physiology …, 2014 - Springer
The biological effects of fluoride on human health are often extensive, either beneficial or
detrimental. Among the various effects of fluoride exposure in different organs, the …