Fatty acid and fat synthesis in the liver is a highly regulated metabolic pathway that is
important for very low-density lipoprotein (VLDL) production and thus energy distribution to …

A high carbohydrate diet up-regulates the transcription of enzymes of triglyceride
biosynthesis (lipogenesis) in the mammalian liver. This treatment stimulates hepatic insulin …

Steatosis is an accumulation of triglycerides in the liver. Although an excessive availability of
plasma fatty acids is an important determinant of steatosis, lipid synthesis from glucose …

The liver is a central organ that controls systemic energy homeostasis and nutrient
metabolism. Dietary carbohydrates and lipids, and fatty acids derived from adipose tissue …

Fat build‐up is determined by the balance between lipogenesis and lipolysis/fatty acid
oxidation. In the past few years, our understanding of the nutritional, hormonal and …

Transcription of enzymes involved in FA and TAG synthesis is coordinately induced in
lipogenic tissues by feeding and insulin treatment. The three major transcription factors …

Sterol regulatory element-binding protein (SREBP)-1c is now well established as a key
transcription factor for the regulation of lipogenic enzyme genes such as FAS in hepatocytes …

The liver is a major site for carbohydrate metabolism (glycolysis and glycogen synthesis)
and triglyceride synthesis (lipogenesis). In the last decade, increasing evidence has …

In mammals, the regulation of hepatic metabolism plays a key role in whole body energy
balance, since the liver is the major site of carbohydrate metabolism (glycolysis and …

Transcription of a number of genes involved in lipogenesis is stimulated by dietary
carbohydrate in the mammalian liver. Both insulin and increased glucose metabolism have …