Although the cardinal manifestations of Parkinson's disease (PD) are attributed to a decline
in dopamine levels in the striatum, a breadth of non-motor features and treatment-related …

Parkinson's disease (PD) is a neuropsychiatric disease affecting approximately 1–2% of the
general population. The classical triad of symptoms, tremor, rigidity, and bradykinesia is …

The understanding of Parkinson's disease (PD) classically revolves around dopamine
depletion within the striatum. However, PD is a multi-systemic disease in which extra …

Parkinson's disease (PD) is a common, late-onset neurodegenerative disorder that shows
progressive extrapyramidal motor disorders (eg, bradykinesia, resting tremors, muscle …

Parkinson's disease is a chronic neurodegenerative disorder characterized by the motor
symptoms of bradykinesia, tremor, rigidity and postural instability. However, non-motor …

Growing evidence suggests that Parkinson′ s disease is not solely affecting the
dopaminergic system. Results from biochemical, animal, postmortem, and functional …

Depression is the most common neuropsychiatric co-morbidity in Parkinson's disease (PD).
The underlying mechanism of depression in PD is complex and likely involves biological …

The neurotransmitter serotonin (5-HT) has a multifaceted function in the modulation of
information processing through the activation of multiple receptor families, including G …

Impulsivity is common in Parkinson's disease even in the absence of impulse control
disorders. It is likely to be multifactorial, including a dopaminergic 'overdose'and structural …

Several recent studies have emphasized a crucial role for the interactions between
serotonergic and dopaminergic systems in movement control and the pathophysiology of …