Stroke remains the leading cause of long-term disability with limited options available to aid
in recovery. Significant effort has been made to try and minimize neuronal damage following …

More than 30 neurotrophins have been identified, and many of them have neuroprotective
effects in brain ischemia or injury. However, all the clinical trials with several neurotrophins …

Traumatic brain injury (TBI) is a major health problem worldwide. Following primary
mechanical insults, a cascade of secondary injuries often leads to further neural tissue loss …

Neurotrophins are a collection of structurally and functionally related proteins. They play
important roles in many aspects of neural development, survival, and plasticity. Traumatic …

The neurotrophins (NTs) nerve growth factor (NGF), brain‐derived neurotrophic factor
(BDNF), NT‐3, and NT‐4/5 are proteins that regulate cell proliferation, differentiation, and …

Ischemic stroke and traumatic brain injury (TBI) are among the leading causes of death and
disability worldwide with impairments ranging from mild to severe. Many therapies are …

Neurodegenerative diseases represent a major public health problem, but beneficial clinical
treatment with neurotrophic factors has not been established yet. The therapeutic use of …

Stroke is the leading cause of adult disability. Systemic delivery of candidate neural repair
therapies is limited by the blood–brain barrier and off-target effects. We tested a …

Traumatic brain injury (TBI) is a major cause of morbidity and mortality among young
individuals worldwide. Understanding the pathophysiology of neurotrauma is crucial for the …

Small molecule drugs have not been effective neuroprotective agents in either the acute
treatment of stroke or the chronic treatment of neurodegeneration. Thus, it is time to consider …