Introduction: Obesity is a well-known global pandemic that is fundamentally caused by an
energy imbalance between calories consumed and calories expended. A major …

Often, chemotherapy by doxorubicin (Adriamycin®) is limited due to life threatening
cardiotoxicity in patients during and posttherapy. Recently, we have shown that moderate …

Purpose A high-fat diet has been shown to exacerbate the cardiotoxicity associated with the
chemotherapy drug doxorubicin (DOX); however, it is unknown whether switching from a …

Introduction: Doxorubicin (DOX) is a widely used chemotherapeutic agent with known
cardiotoxic properties, while calorie restriction (CR) and exercise have well-documented …

Background Breast cancer is a major health burden for women, worldwide. Lifestyle-related
risk factors, such as obesity and being overweight, have reached epidemic proportions and …

Clinical use of doxorubicin (Adriamycin®), an antitumor agent, is limited by its oxyradical-
mediated cardiotoxicity. We tested the hypothesis that moderate diet restriction protects …

Background Childhood cancer survivors have about 15‐times higher risk of heart failure
than their siblings mainly due to the cardiotoxicity of chemotherapy. Nearly 50% of pediatric …

Purpose Trastuzumab (TRZ) is believed to potentiate doxorubicin (DOX) cardiotoxicity,
resulting in left ventricular dysfunction. There is some evidence that overweight could …

Doxorubicin (DOX) is a highly effective antineoplastic agent used in the treatment of various
cancers. Conversely, DOX treatment can result in acute and chronic cardiotoxicity and may …

Doxorubicin (DOX) is a highly effective chemotherapeutic agent used in the treatment of
many solid tumor, blood and gynecological cancers. However, its use is associated with …