Extensive study has demonstrated that epilepsy occurs with greater frequency at certain
times in the 24‐h cycle. Although these findings implicate an overlap between the circadian …

The relationship between circadian rhythm and epilepsy has been recognized for decades.
Yet many questions underlying the complex mechanisms of their interaction remain elusive …

Seizure patterns observed in patients with epilepsy suggest that circadian rhythms and
sleep/wake mechanisms play some role in the disease. This review addresses key topics in …

The circadian pattern of seizures in people with epilepsy was first described two millennia
ago. However, these phenomena have not received enough scientific attention, possibly …

Objectives Growing evidence demonstrates a relationship between epilepsy and the
circadian system. However, relatively little is known about circadian function in disease …

Gene and protein expressions display circadian oscillations, which can be disrupted in
diseases in most body organs. Whether these oscillations occur in the healthy hippocampus …

The occurrence of seizures at specific times of the day has been consistently observed for
centuries in individuals with epilepsy. Electrophysiological recordings provide evidence that …

Growing evidence shows the bidirectional interactions between sleep, circadian rhythm, and
epilepsy. Comprehending how these interact with each other may help to advance our …

Personalized medicine requires that treatments adapt to not only the patient but also
changing factors within each individual. Although epilepsy is a dynamic disorder …

Circadian rhythms are endogenously-mediated 24 h cycles of behavioral or physiological
activity. The interactions among the mammalian circadian clock, acute seizures, and chronic …