A comprehensive analysis and anti-cancer activities of quercetin in ROS-mediated cancer and cancer stem cells

P Biswas, D Dey, PK Biswas, TI Rahaman… - International journal of …, 2022 - mdpi.com
Reactive oxygen species (ROS) induce carcinogenesis by causing genetic mutations,
activating oncogenes, and increasing oxidative stress, all of which affect cell proliferation …

Interfering with ROS metabolism in cancer cells: the potential role of quercetin

L Gibellini, M Pinti, M Nasi, S De Biasi, E Roat… - Cancers, 2010 - mdpi.com
A main feature of cancer cells, when compared to normal ones, is a persistent pro-oxidative
state that leads to an intrinsic oxidative stress. Cancer cells have higher levels of reactive …

Molecular mechanisms of action of quercetin in cancer: recent advances

D Kashyap, S Mittal, K Sak, P Singhal, HS Tuli - Tumor Biology, 2016 - Springer
In the last few decades, the scientific community has discovered an immense potential of
natural compounds in the treatment of dreadful diseases such as cancer. Besides the …

Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health

RA Rather, M Bhagat - Cancer medicine, 2020 - Wiley Online Library
Cancer is a life‐threatening disease afflicting human health worldwide. Recent advances in
drug discovery infrastructure and molecular approaches have helped a lot in identifying the …

Quercetin inhibits proliferation and invasion acts by up-regulating miR-146a in human breast cancer cells

S Tao, H He, Q Chen - Molecular and cellular biochemistry, 2015 - Springer
Breast cancer is the most common female malignancies in the world which seriously impacts
the female health. In recent years, various studies have been reported to determine the …

Potential therapeutic targets of quercetin, a plant flavonol, and its role in the therapy of various types of cancer through the modulation of various cell signaling …

SA Almatroodi, MA Alsahli, A Almatroudi, AK Verma… - Molecules, 2021 - mdpi.com
Polyphenolic flavonoids are considered natural, non-toxic chemopreventers, which are most
commonly derived from plants, fruits, and vegetables. Most of these polyphenolics exhibit …

Site-specific anticancer effects of dietary flavonoid quercetin

K Sak - Nutrition and cancer, 2014 - Taylor & Francis
Food-derived flavonoid quercetin, widely distributed in onions, apples, and tea, is able to
inhibit growth of various cancer cells indicating that this compound can be considered as a …

Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets

P Asgharian, AP Tazekand, K Hosseini… - Cancer cell …, 2022 - Springer
Over the past few years, the cancer-related disease has had a high mortality rate and
incidence worldwide, despite clinical advances in cancer treatment. The drugs used for …

Targets involved in the anti-cancer activity of quercetin in breast, colorectal and liver neoplasms

A Maugeri, A Calderaro, GT Patanè, M Navarra… - International Journal of …, 2023 - mdpi.com
Phytochemicals have long been effective partners in the fight against several diseases,
including cancer. Among these, flavonoids are valuable allies for both cancer prevention …

Quercetin modulates signaling pathways and induces apoptosis in cervical cancer cells

M Kedhari Sundaram, R Raina, N Afroze… - Bioscience …, 2019 - portlandpress.com
Cancer cells have the unique ability to overcome natural defense mechanisms, undergo
unchecked proliferation and evade apoptosis. While chemotherapeutic drugs address this …