Polygenic risk scores (PRS) are promising for identifying common variant‐related
inheritance for psychiatric conditions but their integration into clinical practice depends on …

Studying the phenotypic manifestations of increased genetic liability for schizophrenia can
increase our understanding of this disorder. Specifically, information from alleles identified in …

Objective: Individuals at high risk for schizophrenia may benefit from early intervention, but
few validated risk predictors are available. Genetic profiling is one approach to risk …

Polygenic risk scores (PRS) may aid in the identification of individuals at-risk for psychiatric
disorders, treatment optimization, and increase in prognostic accuracy. PRS may also add …

BACKGROUND: Individuals at high risk schizophrenia may benefit from early intervention
but few validated risk predictors are available. Genetic profiling is one approach to risk …

Major psychiatric disorders are heritable but they are genetically complex. This means that,
with certain exceptions, single gene markers will not be helpful for diagnosis. However, we …

Most general population risk for schizophrenia is accounted for by common variations in the
genome, but each variant explains only a tiny fraction of increased risk. In contrast …

Over the past few years, strong evidence has accumulated that risk for schizophrenia is
influenced by a very large number of common genetic variants that individually increase risk …

Background The polygenic risk score (PRS) for schizophrenia, derived from very large
numbers of weakly associated genetic markers, has been repeatedly shown to be robustly …

Importance Polygenic risk scores (PRS) are predictors of the genetic susceptibility to
diseases, calculated for individuals as weighted counts of thousands of risk variants in which …