[HTML][HTML] The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation

A Plotnikov, E Zehorai, S Procaccia, R Seger - Biochimica et Biophysica …, 2011 - Elsevier
The MAPK cascades are central signaling pathways that regulate a wide variety of
stimulated cellular processes, including proliferation, differentiation, apoptosis and stress …

The subcellular localization of MEK and ERK—a novel nuclear translocation signal (NTS) paves a way to the nucleus

E Zehorai, Z Yao, A Plotnikov, R Seger - Molecular and cellular …, 2010 - Elsevier
The ERK cascade is a central signaling pathway that regulates a large number of
intracellular processes including proliferation, differentiation, development and also survival …

[HTML][HTML] Identification and characterization of a general nuclear translocation signal in signaling proteins

D Chuderland, A Konson, R Seger - Molecular cell, 2008 - cell.com
Upon stimulation, many proteins translocate into the nucleus in order to regulate a variety of
cellular processes. The mechanism underlying the translocation is not clear since many of …

Nuclear extracellular signal-regulated kinase 1 and 2 translocation is mediated by casein kinase 2 and accelerated by autophosphorylation

A Plotnikov, D Chuderland, Y Karamansha… - … and cellular biology, 2011 - Am Soc Microbiol
The extracellular signal-regulated kinases (ERK) 1 and 2 (ERK1/2) are members of the
mitogen-activated protein kinase [MAPK] family. Upon stimulation, these kinases translocate …

The nuclear translocation of mitogen-activated protein kinases: molecular mechanisms and use as novel therapeutic target

K Flores, SS Yadav, AA Katz, R Seger - Neuroendocrinology, 2019 - karger.com
The mitogen-activated protein kinase (MAPK) cascades are central signaling pathways that
play a central role in the regulation of most stimulated cellular processes including …

[HTML][HTML] Evidence for existence of a nuclear pore complex-mediated, cytosol-independent pathway of nuclear translocation of ERK MAP kinase in permeabilized cells

Y Matsubayashi, M Fukuda, E Nishida - Journal of Biological Chemistry, 2001 - ASBMB
The classical mitogen-activated protein kinase (MAPK, also known as ERK) pathway is
widely involved in eukaryotic signal transductions. In response to extracellular stimuli, MAPK …

[HTML][HTML] Two co‐existing mechanisms for nuclear import of MAP kinase: passive diffusion of a monomer and active transport of a dimer

M Adachi, M Fukuda, E Nishida - The EMBO journal, 1999 - embopress.org
In response to extracellular stimuli, mitogen‐activated protein kinase (MAPK, also known as
ERK) translocates from the cytoplasm to the nucleus. MAP kinase kinase (MAPKK, also …

[HTML][HTML] Nuclear ERK: mechanism of translocation, substrates, and role in cancer

G Maik-Rachline, A Hacohen-Lev-Ran… - International journal of …, 2019 - mdpi.com
The extracellular signal-regulated kinases 1/2 (ERK) are central signaling components that
regulate stimulated cellular processes such as proliferation and differentiation. When …

[HTML][HTML] Cytoplasmic localization of mitogen-activated protein kinase kinase directed by its NH2-terminal, leucine-rich short amino acid sequence, which acts as a …

M Fukuda, I Gotoh, Y Gotoh, E Nishida - Journal of Biological Chemistry, 1996 - ASBMB
Mitogen-activated protein kinase (MAPK) is activated in cytoplasm in response to
extracellular signals and then is translocated to nucleus. A directed activator for MAPK …

Signal transduction through MAP kinase cascades

TS Lewis, PS Shapiro, NG Ahn - Advances in cancer research, 1998 - Elsevier
Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …