Efficacy and safety of bempedoic acid among patients with and without diabetes: prespecified analysis of the CLEAR Outcomes randomised trial
KK Ray, SJ Nicholls, N Li, MJ Louie… - The Lancet Diabetes & …, 2024 - thelancet.com
Background Statins reduce LDL cholesterol and cardiovascular events among those with or
without diabetes but have been reported to increase new-onset diabetes. The CLEAR …
without diabetes but have been reported to increase new-onset diabetes. The CLEAR …
Bempedoic acid in patients with type 2 diabetes mellitus, prediabetes, and normoglycaemia: a post hoc analysis of efficacy and glycaemic control using pooled data …
Aim To evaluate the effect of bempedoic acid on glycaemic and lipid variables in patients
with hypercholesterolaemia. Methods A patient‐level pooled analysis of four phase 3 …
with hypercholesterolaemia. Methods A patient‐level pooled analysis of four phase 3 …
Efficacy and safety of bempedoic acid for prevention of cardiovascular events and diabetes: a systematic review and meta-analysis
X Wang, Y Zhang, H Tan, P Wang, X Zha… - Cardiovascular …, 2020 - Springer
Background Bempedoic acid is an oral, once-daily, first-in-class drug being developed for
the treatment of hyperlipidemia. However, evidence of bempedoic acid use for the …
the treatment of hyperlipidemia. However, evidence of bempedoic acid use for the …
Effect of bempedoic acid on new onset or worsening diabetes: a meta-analysis
W Masson, M Lobo, A Lavalle-Cobo, G Masson… - diabetes research and …, 2020 - Elsevier
Introduction Bempedoic acid is a new agent that reduces low-density lipoprotein cholesterol.
Since inhibits cholesterol synthesis through a different mechanism than statins, the adverse …
Since inhibits cholesterol synthesis through a different mechanism than statins, the adverse …
[HTML][HTML] Bempedoic acid in the management of lipid disorders and cardiovascular risk. 2023 position paper of the International Lipid Expert Panel (ILEP)
Cardiovascular disease (CVD) is a chronic non-communicable disease (NCD) and the
predominant cause of morbidity and mortality worldwide. Substantial reductions in the CVD …
predominant cause of morbidity and mortality worldwide. Substantial reductions in the CVD …
Clinical efficacy and safety outcomes of bempedoic acid for LDL-C lowering therapy in patients at high cardiovascular risk: a systematic review and meta-analysis
Y Lin, C Parco, A Karathanos, T Krieger, V Schulze… - BMJ open, 2022 - bmjopen.bmj.com
Objectives Bempedoic acid (BA) is a novel oral low-density lipoprotein cholesterol lowering
drug. This systematic review and meta-analysis aims to assess efficacy and safety for clinical …
drug. This systematic review and meta-analysis aims to assess efficacy and safety for clinical …
Impact of Bempedoic acid on Total cardiovascular events: a Prespecified analysis of the CLEAR outcomes randomized clinical trial
Importance The ATP citrate lyase (ACL) inhibitor, bempedoic acid, reduces low-density
lipoprotein cholesterol (LDL-C) level and major adverse cardiovascular events (MACE) by …
lipoprotein cholesterol (LDL-C) level and major adverse cardiovascular events (MACE) by …
Association of bempedoic acid administration with atherogenic lipid levels in phase 3 randomized clinical trials of patients with hypercholesterolemia
Importance Additional lipid-lowering therapy options are needed for patients who cannot
achieve sufficient decreases in low-density lipoprotein cholesterol (LDL-C) levels using …
achieve sufficient decreases in low-density lipoprotein cholesterol (LDL-C) levels using …
Cardiovascular events in patients treated with bempedoic acid vs. placebo: systematic review and meta-analysis
D Mutschlechner, M Tscharre, K Huber… - European Heart …, 2023 - academic.oup.com
Aims Reduction of low-density lipoprotein cholesterol (LDL-C) decreases cardiovascular
mortality and morbidity. Bempedoic acid represents a promising novel lipid-modifying agent …
mortality and morbidity. Bempedoic acid represents a promising novel lipid-modifying agent …
Mechanism of action and therapeutic use of bempedoic acid in atherosclerosis and metabolic syndrome
G Biolo, P Vinci, A Mangogna, M Landolfo… - Frontiers in …, 2022 - frontiersin.org
Bempedoic acid is a new cholesterol-lowering drug, which has recently received US FDA
and EMA approval. This drug targets lipid and glucose metabolism as well as inflammation …
and EMA approval. This drug targets lipid and glucose metabolism as well as inflammation …
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