Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system

N Hattori - Growth Hormone & IGF Research, 2009 - Elsevier
Immune and neuroendocrine systems have bidirectional communications. Growth hormone
(GH) and an orexigenic hormone ghrelin are expressed in various immune cells such as T …

The effects of ghrelin on inflammation and the immune system

D Baatar, K Patel, DD Taub - Molecular and cellular endocrinology, 2011 - Elsevier
A number of hormones and metabolic mediators signal the brain of changes in the body's
energy status and when an imbalance occurs; the brain coordinates the appropriate …

GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils

N Hattori, T Saito, T Yagyu, BH Jiang… - The Journal of …, 2001 - academic.oup.com
We examined GH and GH receptor expression in human leukemic cell lines and leukocytes
of normal subjects to elucidate the cell types expressing GH and GH receptor, the individual …

Lymphocyte GH-axis hormones in immunity

DA Weigent - Cellular immunology, 2013 - Elsevier
The production and utilization of common ligands and their receptors by cells of the immune
and neuroendocrine systems constitutes a biochemical information circuit between and …

Effects of ghrelin on the proliferation and secretion of splenic T lymphocytes in mice

Q Xia, W Pang, H Pan, Y Zheng, JS Kang, SG Zhu - Regulatory peptides, 2004 - Elsevier
Ghrelin, a novel gut–brain peptide predominantly produced by the stomach, displays strong
growth hormone (GH)-releasing activity mediated by the hypothalamus–pituitary GH …

Novel connections between the neuroendocrine and immune systems: the ghrelin immunoregulatory network

DD Taub - Vitamins & Hormones, 2007 - Elsevier
There appears to be bidirectional communication between the neuroendocrine and immune
systems. This communication is mediated by way of an array of cytokines, hormones, and …

Ghrelin inhibits leptin-and activation-induced proinflammatory cytokine expression by human monocytes and T cells

VD Dixit, EM Schaffer, RS Pyle… - The Journal of …, 2004 - Am Soc Clin Investig
Ghrelin, a recently described endogenous ligand for the growth hormone secretagogue
receptor (GHS-R), is produced by stomach cells and is a potent circulating orexigen …

Ghrelin as an anti-sepsis peptide

N Mathur, SF Mehdi, M Anipindi, M Aziz… - Frontiers in …, 2021 - frontiersin.org
Sepsis continues to produce widespread inflammation, illness, and death, prompting
intensive research aimed at uncovering causes and therapies. In this article, we focus on …

Growth hormone can act as a cytokine controlling survival and proliferation of immune cells: new insights into signaling pathways

S Jeay, GE Sonenshein, MC Postel-Vinay… - Molecular and cellular …, 2002 - Elsevier
While growth hormone (GH) is classically defined as a peptide hormone, recent evidence
supports a role for GH acting as a cytokine in the immune system under conditions of stress …

Physiological effect of ghrelin on body systems

Y Akalu, MD Molla, G Dessie… - International journal of …, 2020 - Wiley Online Library
Ghrelin is a relatively novel multifaceted hormone that has been found to exert a plethora of
physiological effects. In this review, we found/confirmed that ghrelin has effect on all body …