Vectofusin-1 improves transduction of primary human cells with diverse retroviral and lentiviral pseudotypes, enabling robust, automated closed-system manufacturing
C Radek, O Bernadin, K Drechsel, N Cordes… - Human gene …, 2019 - liebertpub.com
Cell and gene therapies are finally becoming viable patient treatment options, with both T
cell-and hematopoietic stem cell (HSC)-based therapies being approved to market in …
cell-and hematopoietic stem cell (HSC)-based therapies being approved to market in …
Vectofusin-1 promotes RD114-TR-pseudotyped lentiviral vector transduction of human HSPCs and T lymphocytes
C Piovan, V Marin, C Scavullo, S Corna… - … Therapy Methods & …, 2017 - cell.com
Ex vivo transduction of human CD34+ hematopoietic stem/progenitor cells (hCD34+
HSPCs) and T lymphocytes is a key process that requires high efficiency and low toxicity to …
HSPCs) and T lymphocytes is a key process that requires high efficiency and low toxicity to …
Vectofusin-1, a new viral entry enhancer, strongly promotes lentiviral transduction of human hematopoietic stem cells
D Fenard, D Ingrao, A Seye, J Buisset, S Genries… - … Therapy-Nucleic Acids, 2013 - cell.com
Gene transfer into hCD34+ hematopoietic stem/progenitor cells (HSCs) using human
immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors (LVs) has several promising …
immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors (LVs) has several promising …
Molecular determinants of vectofusin-1 and its derivatives for the enhancement of lentivirally mediated gene transfer into hematopoietic stem/progenitor cells
Gene delivery into hCD34+ hematopoietic stem/progenitor cells (HSPCs) using human
immunodeficiency virus, type 1-derived lentiviral vectors (LVs) has several promising …
immunodeficiency virus, type 1-derived lentiviral vectors (LVs) has several promising …
Lentiviral vector pseudotypes: precious tools to improve gene modification of hematopoietic cells for research and gene therapy
A Gutierrez-Guerrero, FL Cosset, E Verhoeyen - Viruses, 2020 - mdpi.com
Viruses have been repurposed into tools for gene delivery by transforming them into viral
vectors. The most frequently used vectors are lentiviral vectors (LVs), derived from the …
vectors. The most frequently used vectors are lentiviral vectors (LVs), derived from the …
Production of retroviral vectors
AS Coroadinha, L Gama-Norton, AI Amaral… - Current gene …, 2010 - europepmc.org
Retroviral vectors are presently amongst the most widely used vectors in gene therapy
clinical trials to target pathologies of different origins, such as cancers, genetic diseases or …
clinical trials to target pathologies of different origins, such as cancers, genetic diseases or …
Detailed comparison of retroviral vectors and promoter configurations for stable and high transgene expression in human induced pluripotent stem cells
D Hoffmann, JW Schott, FK Geis, L Lange, FJ Müller… - Gene Therapy, 2017 - nature.com
Correction of patient-specific induced pluripotent stem cells (iPSC) upon gene delivery
through retroviral vectors offers new treatment perspectives for monogenetic diseases. Gene …
through retroviral vectors offers new treatment perspectives for monogenetic diseases. Gene …
Highly efficient and selective CAR-gene transfer using CD4-and CD8-targeted lentiviral vectors
Chimeric antigen receptor (CAR)-modified T cells have revealed promising results in the
treatment of cancer, but they still need to overcome various hurdles, including a complicated …
treatment of cancer, but they still need to overcome various hurdles, including a complicated …
Enhancing lentiviral and alpharetroviral transduction of human hematopoietic stem cells for clinical application
JW Schott, D León-Rico, CB Ferreira… - … Therapy Methods & …, 2019 - cell.com
Ex vivo retroviral gene transfer into CD34+ hematopoietic stem and progenitor cells
(HSPCs) has demonstrated remarkable clinical success in gene therapy for monogenic …
(HSPCs) has demonstrated remarkable clinical success in gene therapy for monogenic …
A nontoxic transduction enhancer enables highly efficient lentiviral transduction of primary murine T cells and hematopoietic stem cells
M Delville, T Soheili, F Bellier, A Durand… - … Therapy Methods & …, 2018 - cell.com
Lentiviral vectors have emerged as an efficient, safe therapeutic tool for gene therapy based
on hematopoietic stem cells (HSCs) or T cells. However, the monitoring of transduced cells …
on hematopoietic stem cells (HSCs) or T cells. However, the monitoring of transduced cells …
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