The endoplasmic reticulum (ER) serves as a warehouse for factors that augment and control
the biogenesis of nascent proteins entering the secretory pathway. In turn, this compartment …

The endoplasmic reticulum (ER) is the site of synthesis for nearly one-third of the eukaryotic
proteome and is accordingly endowed with specialized machinery to ensure that proteins …

In eukaryotic cells terminally misfolded proteins of the secretory pathway are retarded in the
endoplasmic reticulum (ER) and subsequently degraded in a ubiquitin‐proteasome …

Quality control of protein folding inside the endoplasmic reticulum (ER) includes chaperone-
mediated assistance in folding and the selective targeting of terminally misfolded species to …

Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins
synthesized in the ER. Through coordinated actions of ERAD components …

The endoplasmic reticulum (ER) is the eukaryotic organelle where most secretory proteins
are folded for subsequent delivery to their site of action. Proper folding of newly synthesized …

The folding of secretory and membrane proteins takes place in the endoplasmic reticulum
(ER). The quality of the proteins folded in the ER is carefully monitored by an ER quality …

All proteins are subject to quality control processes during or soon after their synthesis, and
these cellular quality control pathways play critical roles in maintaining homeostasis in the …

Endoplasmic reticulum-associated protein degradation (ERAD) is a protein quality control
mechanism that minimizes the detrimental effects of protein misfolding in the secretory …

Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded or
unassembled proteins from the ER. ERAD targets are selected by a quality control system …