Benzo [a] pyrene immunogenetics and immune archetype reprogramming of lung
EE Abd El-Fattah, AM Abdelhamid - Toxicology, 2021 - Elsevier
Overexposure to carcinogenic precursor, benzo [a] pyrene [BaP], modulates the lung
immune microenvironment. The present review seeks to elucidate novel pathways behind …
immune microenvironment. The present review seeks to elucidate novel pathways behind …
Immunosuppressive role of Benzo [a] pyrene in induction of lung cancer in mice
ML Salem, NE El-Ashmawy, EE Abd El-Fattah… - Chemico-biological …, 2021 - Elsevier
Aim Benzo [a] pyrene [BP] is one of the major carcinogenic precursors of cigarette smoke
that primary affects the lung at its first proximity. The goal of the current research was to …
that primary affects the lung at its first proximity. The goal of the current research was to …
[HTML][HTML] Benzo [a] pyrene induces fibrotic changes and impairs differentiation in lung stem cells
YH Tseng, YC Chen, LY Alice, J Yu - Ecotoxicology and Environmental …, 2021 - Elsevier
Human activities have generated air pollution, with extremely small particles (PM 2.5,
particulate matter less than 2.5 µm in diameter) and liquid droplets, which become a menace …
particulate matter less than 2.5 µm in diameter) and liquid droplets, which become a menace …
[HTML][HTML] Macrophages promote benzopyrene-induced tumor transformation of human bronchial epithelial cells by activation of NF-κB and STAT3 signaling in a bionic …
E Li, Z Xu, H Zhao, Z Sun, L Wang, Z Guo, Y Zhao… - Oncotarget, 2015 - ncbi.nlm.nih.gov
We investigated the role of macrophages in promoting benzopyrene (BaP)-induced
malignant transformation of human bronchial epithelial cells using a BaP-induced tumor …
malignant transformation of human bronchial epithelial cells using a BaP-induced tumor …
Benzo[a]pyrene at human blood equivalent level induces human lung epithelial cell invasion and migration via aryl hydrocarbon receptor signaling
H Gao, G Ye, Y Lin, Y Chi… - Journal of Applied …, 2020 - Wiley Online Library
Abstract Benzo [a] pyrene (B [a] P), a typical carcinogenic polycyclic aromatic hydrocarbon,
exists worldwide in vehicle exhaust, cigarette smoke and other polluted environments …
exists worldwide in vehicle exhaust, cigarette smoke and other polluted environments …
Inflammatory mediators accelerate metabolism of benzo [a] pyrene in rat alveolar type II cells: the role of enhanced cytochrome P450 1B1 expression
L Šmerdová, J Neča, J Svobodová, J Topinka… - Toxicology, 2013 - Elsevier
Long-term deregulated inflammation represents one of the key factors contributing to lung
cancer etiology. Previously, we have observed that tumor necrosis factor-α (TNF-α), a major …
cancer etiology. Previously, we have observed that tumor necrosis factor-α (TNF-α), a major …
Bisphenol-A/Radiation mediated inflammatory response activates EGFR/KRAS/ERK1/2 signaling pathway leads to lung carcinogenesis incidence
OAR Abo-Zaid, FSM Moawed… - International …, 2022 - journals.sagepub.com
Background Bisphenol (BPA) and ionizing radiation exposure (IR) are potent oxidants that
cause free radical induction, leading to signaling pathway activation that alters cell growth …
cause free radical induction, leading to signaling pathway activation that alters cell growth …
[HTML][HTML] The β-blocker carvedilol prevents benzo (a) pyrene-induced lung toxicity, inflammation and carcinogenesis
A Shahid, M Chen, C Lin, BT Andresen, C Parsa… - Cancers, 2023 - mdpi.com
Simple Summary Benzo (a) pyrene is a ubiquitously present environmental contaminant that
induces lung cancer after being converted into active metabolites via aryl hydrocarbon …
induces lung cancer after being converted into active metabolites via aryl hydrocarbon …
Transcriptional Signature of Human Macrophages Exposed to the Environmental Contaminant Benzo(a)pyrene
L Sparfel, ML Pinel-Marie, M Boize… - Toxicological …, 2010 - academic.oup.com
Polycyclic aromatic hydrocarbons (PAHs) are widely distributed immunotoxic and
carcinogenic environmental contaminants, known to affect macrophages. In order to identify …
carcinogenic environmental contaminants, known to affect macrophages. In order to identify …
Benzo [a] pyrene and tumor necrosis factor-α coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II …
L Umannová, M Machala, J Topinka, J Schmuczerová… - Toxicology letters, 2011 - Elsevier
Alveolar type II epithelial (AEII) cells regulate lung inflammatory response and,
simultaneously, they are a target of environmental carcinogenic factors. We employed an in …
simultaneously, they are a target of environmental carcinogenic factors. We employed an in …