The human placenta fulfills a variety of essential functions during prenatal life. Several ABC
transporters are expressed in the human placenta, where they play a role in the transport of …

Abstract Knowledge concerning transport of maternally administered drugs across the
placental barrier is essential for determining potential toxicity of drugs to the fetus and the …

ATP-binding cassette (ABC) efflux transporters are expressed in the human placenta where
they are thought to help protect the fetus from xenobiotics. To evaluate models for analysis of …

Placental ATP binding cassette (ABC) transporters protect placental and fetal tissues by
effluxing xenobiotics and endogenous metabolites. We have investigated the effects of …

The placenta serves an important role both as a protective barrier as well as in normal fetal
development. The ATP-binding cassette (ABC) proteins perform crucial functions in the …

Pregnant women are often complicated with diseases including viral or bacterial infections,
epilepsy, hypertension, or pregnancy-induced conditions such as depression and …

ABC transporters are ubiquitous in the human body and are responsible for the efflux of
drugs. They are present in the placenta, intestine, liver and kidney, which are the major …

Placental ATP-binding cassette (ABC) transporters limit fetal exposure to xenobiotics by
regulating transplacental passage into the fetal circulation; their expression and function in …

ABSTRACT Introduction: P-glycoprotein (P-gp)/ABCB1 and breast cancer resistance protein
(BCRP)/ABCG2 are highly expressed in the placenta and fetus throughout gestation and …

The human placenta expresses a large number of transport proteins. The ATP-binding
cassette (ABC) family of active efflux pumps, predominantly localised to the maternal-facing …